Common Veterinary Vaccines – PST06107 Basic Veterinary Pharmacology
NTA Level 6 • Semester 1 • PST06107 Common Veterinary Vaccines Basic Veterinary Pharmacology • Source Session/Topic 44 Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability. PST 06107 Basic Veterinary Pharmacology Session 44: Common Veterinary Vaccines Learning Tasks By the end of this session students are expected to be able to: Describe Anthrax vaccine Describe Bovine P asteurellosis vaccine Describe Contagious C aprine PleuroPneumonia (CCPP) vaccine Describe Foot and Mouth disease vaccine Describe Newcastle disease vaccine Describe Avian coccidiosis vaccine Describe Fowlpox vaccine Describe Fowltyhoid vaccine Activity: Buzzing •What is veterinary Vaccines? Anthrax Vaccine Description Freeze-dried live bacterial vaccine produced by using Sterne 34 F2 strain of Bacillus anthracis adjuvated with saponin 4% skimmed milkstabilizer is produced at NVI, Debre Zeit Each field dose contains 107 viable spores Indication For prevention or control of anthrax in domestic animals Anthrax Vaccine Cont … Presentation The freeze-dried vaccine is available in 20 ml vials of 100 doses Dosage and administration Reconstitute the product in 100 ml of sterile saline water. Cattle & equines: 1 ml SC in the loose skin of the neck just in front of the shoulder. Sheep & goats: 0.5 ml SC in the loose skin or in the inner face of the thigh Anthrax Vaccine Cont … Booster Vaccination should be carried out every year before the anthrax season. Immunity Develops in 10 days and lasts for one year Side-effect Swelling at the injection site. It normally disappears in 2-3 days Anthrax Vaccine Cont … Precautions Inject SC only & animals above 3 months of age. Pregnant animals should not be vaccinated. Antibiotic should not be given shortly before and 14 days after vaccination. Destroy empty bottles or if unusable by incinerations . Withdrawal period Meat- for six weeks after vaccination Storage Store in refrigerator at 4˚C Bovine Pasteurellosis Vaccine (Haemorrhagic Septicaemia) Description Prepared from a whole broth culture of Pasteurella multocida type B and Mannheimia haemolytica & P. trehalosi (208 germs/ml), killed by 0.3% formalin and Precipitated by 1% aluminium potassium sulphate (both final concentration ) Dosage and administration For best results vaccinate animals at least 21 days before the hemorrhagic septicemia season Shake the product vigorously before use; inject adult and calves with 2 ml SC . Bovine Pasteurellosis Vaccine (Haemorrhagic Septicaemia ) Cont.…. Immunity Immunity appears in 10 days after vaccination and lasts for 6 to 8 months. Revaccination is advised after 6 months . Side-effects Anaphylactic reactions may appear occasionally after vaccination of Zebus; serious in and very often on cattle breeds, particularly on animals, which have been vaccinated many times against foot-and-mouth disease, Blackleg or Anthrax. Thus sensitiveness should be checked in these breeds before use. In case of reaction, immediate injectioin of antihistamine is recommended Contagious Caprine Pleuropneumonia (CCPP) Vaccine Description It is an inactivated bacterial vaccine produced using F-38 Kenyan strain of Mycoplasma capricolum capripneumoniae ( MccP ) Wellgrown Mycoplasma culture is inactivated by saponin , which has also an adjuvant effect The minimum protein content in each field dose is 0.15 mg/ml Indication To control or prevent CCPP in goat Dosage and administration Shake the vaccine before use and vaccinate 1 ml/goat subcutaneously (thoracic area is advisable) Contagious Caprine Pleuropneumonia (CCPP) Vaccine Cont … Immunity CCPP vaccine confers immunity for 1 year Revaccination should be made after a year Side-effect Slight edematous reaction is induced by the adjuvant, saponin , which disappears in 48hours Storage The vaccine should be stored at +4˚C at least for one Foot and Mouth Disease Vaccine Description A bivalent vaccine manufactured from locally isolated from A and O serotypes are produced by the NVI The virus is propaged from cell culture. It is absorbed into aluminium hydroxide gel and inactivated with 0.3% formaldehyde and adjuved with saponin Indication Control or prevention of Foot and Mouth Disease in cattle Foot and Mouth Disease Vaccine Cont … Dosage and administration Shake the bottle before use and inject 4 ml/head of cattle SC, preferably in dewlap region The first vaccination requires two injections at 6 months of interval Booster Annually and consider the outbreak season Immunity 2-3 weeks after vaccination and may last for one year Foot and Mouth Disease Vaccine Cont.…. Side-effects Swelling may occur at the site of inoculation and persist for few weeks. Precautions After puncture of the stopper the whole bottle of the vaccine must be used within 24 hours Do not vaccinate the cattle under 6 months of age. It is better not to associate other vaccination with FMD and not to make another vaccination one month before and after FMD vaccination Vaccine should be stored at 4˚C Newcastle Vaccine Cont … Description It is a live viral vaccine produced in an embryonated specific pathogen free (SPF) eggs using the relatively heat stable variant strain Each field dose contains at least log 107 ELD 50 viral particles Indication To control or prevent Newcastle disease in poultry Presentation The vaccine is available in vials of 250, 100 and 50 doses . Newcastle Vaccine Cont … Dosage and administration Ocular route Use an eyedropper To calculate the volume of water required to dilute the vaccine into the recommended dose per vial, follow the instructions below Measure 1 ml of water to the dropper Count the number ofdrops in this 1 ml of water Newcastle Vaccine Cont … Ocular route…. Calculate the volume of diluents required to dilute the number of doses of the vaccine per vial with the eyedropper in use Volume of diluents (ml) = No. of doses of vaccine per vial/ No. of drops formed per ml Example, how much diluents should be added to a vial containing 250 doses of NCD vaccine given that 1 ml of water in the eyedropper yielded 50 drops. The answer is; Volume of diluents (ml) = 250 doses per vial/50 drops per ml = 5 ml per vial Newcastle Vaccine Cont … Oral drench Dissolve the