Collection, Processing and Storage of Medicinal Plants – PST05210 Basic Pharmacognosy
NTA Level 5 • Semester 2 • PST05210 Collection, Processing and Storage of Medicinal Plants Basic Pharmacognosy • Source Session/Topic 13 Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability. Session 13: Collection, Processing and Storage of Medicinal Plants Total Session Time: 120 minutes Prerequisites • None Learning Tasks By the end of this session students are expected to be able to: • List methods for collection of medicinal drugs • Explain the importance of processing medicinal plants • Explain methods of drying of crude drugs • Explain storage of medicinal plants Resources Needed: • Flip charts, marker pens, and masking tape • Black/white board and chalk/whiteboard markers • Computer and LCD Projector SESSION OVERVIEW |Step |Time |Activity/ |Content | | | |Method | | |1 |05 minutes |Presentation |Introduction, Learning Tasks | |2 |30 minutes |Presentation |Collection of Medicinal Plants | |3 |45 minutes |Presentation |Processing of Crude Drugs | |4 | |Small group |Storage of Crude Drugs | | |30 minutes |Discussion | | | | |Presentation | | |5 |05 minutes |Presentation |Key Points | |6 |05 minutes |Presentation |Evaluation | SESSION CONTENTS STEP 1: Presentation of Session Title and Learning Tasks (5 minutes) READ or ASK students to read the learning objectives and clarify ASK students if they have any questions before continuing. STEP 2: Collection of Medicinal Plants (30 minutes) • Collection refers to harvesting or obtaining drugs from medicinal plants • Drugs may be collected from wild or cultivated plants • Collection may be done by skilled or unskilled labour • Collection from cultivated plants is more advantageous and ensures sustainability of medicinal plants • In some cases, pharmacopoeias specify collection of certain drugs from cultivated species such as Fennel, ginger, cinnamon and opium • Some drugs e.g. senna, tragacanth and others may be collected from wild or cultivated species. • Active constituents in plants vary in amount and nature throughout the year, so collection should be done at the right time when active constituents are at the highest levels. For instance, o Time (season) of the year ▪ Rhubarb contains high levels of anthranols in winter and high levels of anthraquinones in summer. Anthranol are oxidized to anthraquinones in summer o Time of the day ▪ Digitalis is collected in the afternoon contains more cardiac glycosides ▪ Solanaceous leaves collected in the morning have more alkaloids o Stage of maturity ▪ In Eugenia caryophyllus, buds contain high oil but mother “blown” cloves contain very little oil ▪ Vanilla has highest levels of vanillin 8 months after flowers open • General factors to consider when harvesting/collecting drugs from medicinal plants; o Underground organs are collected when aerial parts die down o Leaves are collected when flowers are beginning to open o Flowers are collected in dry weather and just before they fully expand e.g. cloves o Fruits and seeds are collected when fully mature but unripe o Barks are collected in damp weather o Unorganized drugs are collected in dry weather o Leaves, flowers and fruits should not be collected when covered with dew or rain o Discoloured or parts attacked by insects should not be collected o Large organs should be sliced soon after collection to facilitate drying o Limits of unwanted parts in desired parts must be considered when collecting medicinal plants e.g. aerial stems in rhizomes STEP 3: Processing of Crude Drugs (45 minutes) • After collection, drugs should be processed to meet various requirements such as market requirements • Processing of crude drugs is important in order prevent deterioration • Processing of drugs from natural sources depends on morphological nature, constituents, geographical source and other related factors • Drying is an important aspect of processing crude drugs o There various reasons for drying drugs obtained from medicinal plants ▪ To decrease size and weight i.e. to facilitate packing, transport and storage ▪ To facilitate powdering ▪ To prevent enzyme action ▪ To prevent microbial growth ▪ To prevent degradation of active constituents o Enzyme action may be desired or undesirable after collection ▪ When enzyme action is desired after collection e.g. in vanilla pods, gentian roots and cocoa seeds, the collected drug is dried slowly at moderate temperature ▪ Drying is done as soon as possible after harvesting when enzyme reaction is not desired e.g. digitalis leaves o Methods of Drying o There are various methods that are used in drying crude drugs o The choice of a drying method depends on physical characteristics of the plant and chemical characteristics of the active constituents ▪ Air Drying • Sun Drying o Is done when drugs are not adversely affected by excessive sunlight. o Drugs are dried in thin layers and tuned over occasionally o Drugs dried in this way include clove and cardamom • Shade Drying o Done when sunlight causes discoloration and warping/shrivelling of the drugs e.g. cinnamon ▪ Artificial Drying • Artificial source of heat is used in the drying process • Drying in the oven (oven drying) is the commonest methods used in artificial drying • Artificial drying is more accepted and more rapid than air-drying • Artificial drying is more suitable for use in the wet weather • Drying temperature is governed by constituents o Generally, leaves, herbs and flowers are dried between 20-40oC, barks and roots: 40-65oC • When done rapidly, the drugs retain colour and aroma ▪ Vacuum Drying • It is also done in oven, but at low temperature • Low pressure ensures rapid and complete drying • It is an expensive method and thus reserved for expensive drugs or drugs which cannot be sufficiently dried by other methods ▪ Lyophilisation • Involves freezing of the drug and then evaporation under low pressure • Very suitable method for drugs that are very sensitive to heat • The resulting product is a fine powder • This method is used for drying biological fluids, enzymes, proteins