Pharmacotherapy of African Swine Fever – PST06107 Basic Veterinary Pharmacology

NTA Level 6 • Semester 1 • PST06107

Pharmacotherapy of African Swine Fever

Basic Veterinary Pharmacology • Source Session/Topic 31
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PST 06107

Basic Veterinary Pharmacology

Session 31: Pharmacotherapy

of

African Swine Fever

Learning Tasks

By

the end of this session students are expected to be able to:

Define

African

swine fever

List signs and symptoms of

African

swine fever

Describe pharmacological treatment of

African

swine fever

Describe control and prevention of

African

swine fever

Activity: Buzzing

• What

is African swine fever?

Definition of African Swine Fever

It is a peracute highly contagious and highly fatal disease of pig caused by African swine fever virus

The transmission occurs by Argaside ticks

Once established, the disease spread rapidly by direct contact or ingestion of contaminated feed

Signs and Symptoms of African Swine Fever

Fever

that subside after four days

Development of cyanotic skin

Anorexia

Huddling together

Disinclination to move

Incoordination of hind quarter

Moving using front legs dragging the hind legs

Naso-occular

discharge

Dyspnea and cough

Pharmacological Treatment of African Swine Fever

No

specific treatment but treat with antibiotics for secondary bacterial infection.

Lincomycin

hydrochloride 10-15 mg/kg, IM, q 12 h and with hydrogen peroxide 8.3 mg/kg q 24 h, PO for 3-5 days, or

Oxytetracycline

0.5g/kg of feed for 7 days, and 10-20 mg/kg IV or IM q 6 h for 7 days, or

Trimethoprim-

sulphadiazine

, 15 mg/kg, PO, q 12 h for 3- 5days. or 48 mg/kg, q 24 h, IM

Activity:

Brainstorming

What

are the prevention and control measures for

African

swine fever?

Prevention and Control of African Swine Fever

Maintain

disease free status by restriction of pig movement and serological monitoring and prevention of contact between domestic pigs and warthogs

Prohibition of importation of pigs and pig products

Currently there is no approved vaccine for

ASF

Prevention and Control of African Swine Fever

Cont.…

Prevention depends on implementation of appropriate import policies and biosecurity measures, ensuring that neither infected live pigs nor pork products are introduced into areas free of ASF.

This includes ensuring proper disposal of waste food from aircraft, ships or vehicles coming from affected countries and policing illegal imports of live pigs and pork products from affected countries

Key Points

African

swine fever (ASF) is a highly contagious haemorrhagic viral disease of domestic and wild pigs, which is responsible for serious economic and production losses.

It is caused by a large DNA virus of the

Asfarviridae

family, which also infects ticks of the genus

Ornithodoros

Clinical signs and mortality rates can vary according to the virulence of the virus and the type/species of pig

Prevention depends on implementation of appropriate import policies and biosecurity measures, ensuring that neither infected live pigs nor pork products are introduced into areas free of ASF

Evaluation

What

is African swine fever?

What are the common signs and symptoms of African swine fever?

What is the pharmacological treatment of African swine fever?

What are the control measures against African swine fever?

References

Riviere

J. E.,

Papich

M. G. (2009).

Veterinary Pharmacology and Therapeutics

(9

th

Ed) Iowa, Wiley-

Blackwel

Publishers

Hsu

W. H. (2008).

Handbook of Veterinary Pharmacology

(1

st

Ed) Iowa, Wiley-

Blackwel

Publishers

Kuafmann

J, (1996).

Parasitic infections of domestic animals

, (2

nd

ed

).Berlin,

Birkhäuser

Verlag

Press

Hoare

E. W. (2013).

A manual veterinary therapeutics & pharmacology

(2

nd

ed

),New

York, Forgotten Books

Press

Maddison

. J. (

ed

) (2008).

Small Animal Clinical Pharmacology

, (2nd

ed

). Philadelphia, Saunders Elsevier Limited

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