NTA Level 4 • Semester 1 • PST04105

Calculations of Dosage of Heparin

Pharmaceutical Calculations • Source Session/Topic 12

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Session 12: Calculations of Dosage of Heparin

Total Session Time: 60 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• Calculating dosage of heparin

Resources Needed:

• Flip charts, marker pens, and masking tape

• Black/white board and chalk/whiteboard markers

SESSION OVERVIEW

SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning tasks and clarify

ASK students if they have any questions before continuing.

STEP 2: Definition of Heparin (15 minutes)

|Activity: Brainstorming (5 minutes) |

| |

|Ask students to brainstorm on the following question: |

| |

|What is a Heparin? |

| |

|ALLOW few students to respond |

| |

|WRITE their responses on the flip chart/ board |

| |

|CLARIFY and SUMMARISE by using the content below |

• Heparin is a drug that has anticoagulant properties.

• Heparin slows clotting time and is therefore used as anticoagulant

• There are two types of Heparin preparations:

o Unfractioned Heparin

o Low Molecular weight heparins

• Heparin salts are administered as sterile aqueous solutions by

intravenous infusion, intermittent intravenous injection, or deep

subcutaneous injection.

STEP 3: Calculation of Unfractioned Heparin Dosing (30 minutes).

|Activity: Small Group Discussion ( 20 minutes) |

| |

|DIVIDE students into small manageable groups |

| |

|ASK students to discuss on the following question |

|An intravenous infusion contained 20,000 units of heparin sodium in |

|1000 mL of D5W. The rate of infusion was set at 1600 units per hour for|

|a 160-lb. patient. |

|Calculate: |

|(a) The concentration of heparin sodium in the infusion, in units/mL; |

|(b) The length of time the infusion would run, in hours; |

|(c) The dose of heparin sodium administered to the patient, on a |

|unit/kg/minute basis. |

| |

|ALLOW students to discuss for 15 minutes |

| |

|ALLOW few groups to present and the rest to add points not mentioned |

| |

|CLARIFY and SUMMARIZE by using the contents below |

• The following are the answers of the above exercise:

a) 20000 units/1000mL = 20 units/mL

b) 20000 units/20 units/mL = 12.5hrs

c) 160pounds = 72.7kg

12.5 hrs = 750 minutes

20000 units/750 minutes = 26.67 unit/minute

26.67 unit/minute / 72.7 kg = 0.37 units/kg/min Answers

STEP 4: Key Points (5 minutes)

• Heparin is used as anticoagulant; however, its use carries with it, the

risk of hemorrhage

• Bolus doses, given by direct intravenous injection, may be followed by

intravenous infusion as a heparin drip

• Low-dose heparin administration provides effective prophylaxis (rather

than therapeutic effects) in a variety of surgical procedures

STEP 5: Evaluation (5 minutes)

• What is Heparin?

• How do you calculate the dose of Heparin?

References

Ansel, H. C & Stocklosa, M. J. (2001). Pharmaceutical Calculations (11th

ed.). Philadelphia, United States: LIPPINCOTT WILLIAMS & WILKINS

Ansel, H. C (2010) Pharmaceutical Calculations (13rd ed.). Philadelphia,

United States: LIPPINCOTT WILLIAMS & WILKINS

Senya, S. S, Mwasha, C.Y, Muyinga, A. M, Amiri,R. I. and Mauga E.A.S.K.

(2011) Tanzania Pharmaceutical Handbook (2nd ed.). Dar eS Salaam,

Tanzania: School of Pharmaceutical Sciences.

Zatz, J.L and Teixeira, M.G. (2005). Pharmaceutical Calculation (4th ed.).

New Jersey: John Wiley & Sons, Inc

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