Gelatin Capsules: Hard Gelatin Capsule Manufacture (Part 2)
Explore “Hard Gelatin Capsule Manufacture” in this Gelatin Capsules lesson. Part 2 of the five-part series brings together the source material and lesson topics. Use the contents links to find a section, read the notes, and consult the complete original teaching slides below.
Lesson topics
- HARD GELATIN CAPSULES
- MANUFACTURE OF EMPTY GELATIN CAPSULES:
- DIPPING :
- TRIMMING AND JOINING
- Filling of Hard Gel capsules
Contents
- Read the original document
- HARD GELATIN CAPSULES
- MANUFACTURE OF EMPTY GELATIN CAPSULES:
- DIPPING :
- TRIMMING AND JOINING
- Filling of Hard Gel capsules
- FILLING OF HARD GELATIN CAPSULES:
- Developing and preparing formulation.
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Read the original source document
Capsules – Naresh Gorantla: original teaching slides for this study series.
HARD GELATIN CAPSULES
HARD GELATIN CAPSULES These are used for administration of solid medicaments. The capsule shell is prepared from gelatin. It consists of two parts i.e. body and cap. The powdered material is filled into the cylindrical body of the capsules and then the cap is placed over it. contain 12 – 16 % moisture typically filled with dry solids SIZE | VOLUME (cm3) 000 | 1.37 00 | 0.95
MANUFACTURE OF EMPTY GELATIN CAPSULES:
MANUFACTURE OF EMPTY GELATIN CAPSULES: Steps involved in making empty gelatin capsules… Stripping Polishing
DIPPING :
DIPPING : Pairs of the stainless steel pins are dipped into the dipping solution to simultaneously form the caps and bodies. The dipping solution is maintained at a temperature of about 50 degree centigrade in a heated ,jacketed dipping pan. SPINNING: The pins are rotated to distribute the gelatin over the pins unifomly and to avoid the formation of a bead at the capsule ends.
The gelatin is dried by a blast of cool air to form a hard shells. The pins are moved through a series of air drying kilns to remove water STRIPPING : A series of bronze jaws strip the cap and body portions of the capsules from the pins.
TRIMMING AND JOINING
The stripped cap and body portions are trimmed to the required length by stationary knives. After trimming to the right length, the cap and body portion are joined and ejected from the machine. POLISHING Pan Polishing : Acela-cota pan is used to dust and polish. Cloth Dusting : Capsule are rubbed with cloth. Brushing : Capsule are feed under soft rotating brush. TRIMMING AND JOINING
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Filling of Hard Gel capsules
Filling of Hard Gel capsules
FILLING OF HARD GELATIN CAPSULES:
FILLING OF HARD GELATIN CAPSULES: Punch Method or Manual Filling. Hand Filling or Semi Automatic Capsules Devices. Automatic filling machine. Various Filling Machine Available… Hofliger and Karg Zanasi Nigris Parke-Davis Macofar SAS These machine differ in there design and output
Developing and preparing formulation.
In large scale or small preparations of filled hard gelatin capsules divided into the following general steps: Developing and preparing formulation. Filling the capsule shell Capsule sealing Cleaning and polishing the filled capsules. Diluents and fillers: lactose, microcrystaline cellulose, starch. Disintegrants: sodium starch glycolate , pregelatinised starch
Gligants and lubricants: silicon dioxide, magnesium stearte, calcium stearate Wetting agents: SLS
Review questions and answers
What are the key points about HARD GELATIN CAPSULES?
HARD GELATIN CAPSULES These are used for administration of solid medicaments. The capsule shell is prepared from gelatin. It consists of two parts i.e. body and cap. The powdered material is filled into the cylindrical body of the capsules and then the cap is placed over it. contain 12 – 16 % moisture typically filled with dry solids SIZE | VOLUME (cm3) 000…
What are the key points about MANUFACTURE OF EMPTY GELATIN CAPSULES:?
MANUFACTURE OF EMPTY GELATIN CAPSULES: Steps involved in making empty gelatin capsules… Stripping Polishing
What are the key points about DIPPING 😕
DIPPING : Pairs of the stainless steel pins are dipped into the dipping solution to simultaneously form the caps and bodies. The dipping solution is maintained at a temperature of about 50 degree centigrade in a heated ,jacketed dipping pan. SPINNING: The pins are rotated to distribute the gelatin over the pins unifomly and to avoid the formation of a bead…
What are the key points about TRIMMING AND JOINING?
The stripped cap and body portions are trimmed to the required length by stationary knives. After trimming to the right length, the cap and body portion are joined and ejected from the machine. POLISHING Pan Polishing : Acela-cota pan is used to dust and polish. Cloth Dusting : Capsule are rubbed with cloth. Brushing : Capsule are feed under soft rotating…
What are the key points about FILLING OF HARD GELATIN CAPSULES:?
FILLING OF HARD GELATIN CAPSULES: Punch Method or Manual Filling. Hand Filling or Semi Automatic Capsules Devices. Automatic filling machine. Various Filling Machine Available… Hofliger and Karg Zanasi Nigris Parke-Davis Macofar SAS These machine differ in there design and output
More lessons from this document
- Capsules – Naresh Gorantla — Part 1
- Capsules – Naresh Gorantla — Part 2
- Capsules – Naresh Gorantla — Part 3
- Capsules – Naresh Gorantla — Part 4
- Capsules – Naresh Gorantla — Part 5
Conclusion
The important points in Important Concepts should be reviewed alongside the definitions, examples and comparisons given above. Continue with the other four articles to cover the rest of the source material.