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DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Inflammation And Wound Healing CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Inflammation And Wound Healing using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic INFLAMMATION AND WOUND HEALING Definition Cardinal signs of inflammation How to name the inflammation Acute inflammation Persistent arteriolar dilatation to increase blood flow in the affected site; leads to heat and redness( erythema) 2. Cellular phase After adhesion, leukocytes move to the extracellular space through the gap in the endothelial cells (emigration) The steps of the inflammatory response SPECIAL TYPES OF INFLAMATION CHRONIC INFLAMMATION Two major characteristic features of chronic inflammation causes ii. Persistent indigestible material. iv. Hypersensitivity reactions; inappropriate immune response to generally harmless antigen. MACROPHAGE IN CHRONIC INFL. Diseases involving chronic inflammation. Management WOUND HEALING Angiogenesis : formation of new blood vessels to supply oxygen and nutrients to the healing tissue Pathological issues in wound healing Key players Bone healing involves several stages Systemic factors INFLAMMATION AND WOUND HEALING Ms.Happy.BscMIR.2025. Definition Inflammation is dynamic process by which living vascularized tissues reacts to injury. Causes Physical e.g. trauma, temperature, radiation Infection e.g. bacteria, viruses, parasites Chemical e.g. acids, organic compounds Immunological e.g. antigen-antibody Under normal circumstances inflammation is a protective response, a goal of which is to eliminate the initial cause of injury, however if triggered or directed inappropriately, inflammatory response itself can be harmful and cause tissue and organ destruction. Cardinal signs of inflammation Rubor(redness): dilatation of small blood vessels in damaged area. Calor(heat): increased blood flow(hyperemia) Tumor(swelling): accumulation of fluid in interstitial space(edema) Dolor(pain):distortion of tissue from edema especially pus. Loss of function: movement hindered How to name the inflammation Using suffix – itis after the name of the organs/site involved Eg Pancreatitis Hepatitis Encephalitis Meningitis Peritonitis Myocarditis This is not applicable to other organs/sites,eg:- Pleurisy- inflammation of the pleura Pneumonia- inflammation of the lungs Acute inflammation Is a rapid response to injurious stimuli, short acting, minutes to days. Pathogenesis of events Vascular phase Tissue injury Release of chemical for local response (histamine, prostaglandin, bradykinin, leukotriene etc) The immediate response is vasoconstriction, it may last about 3-5 sec, even 5 min depends on severity. Persistent arteriolar dilatation to increase blood flow in the affected site; leads to heat and redness( erythema) When the volume of blood increases, it increases intravascular hydrostatic pressure, so fluid from capillaries migrate to the tissue (exudate) 2. Cellular phase It is marked by two major events Leukocyte (WBC) movement Plasma or fluid gets discharged from the blood due to increased permeability(migration) The leukocyte in the surface contain integrin protein and endothelial cell of blood capillary consists of selectins( P&E) proteins on their surface. During the leukocyte rolling on to the endothelial cell, integrin and selectin get activated. They produce adhesion on the capillary of endothelial cell. After adhesion, leukocytes move to the extracellular space through the gap in the endothelial cells (emigration) At the site of injury several mediators get released which attract the leukocytes.( chemotaxis process) Phagocytosis Engulfment of solid particle or an agent ( cell eating) After the engulfment phagocyte release the lysosomes or degrading enzymes. This process fails to kill bacteria like m.tuberculosis The steps of the inflammatory response can be remembered as the five Rs: (1) Recognition of the injurious agent (2) Recruitment of leukocytes, (3) Removal of the agent, (4) Regulation (control) of the response, (5) Resolution (repair). SPECIAL TYPES OF INFLAMATION Catarrhal inflammation- exudative inflammation occurring exclusively on the mucous membranes of respiratory and gastrointestinal tracts and producing watery exudate of serum and mucus. Hemorrhagic inflammation:-when damage is severe there is rupture of blood vessel where hemorrhage is most striking feature, eg hemorrhagic pneumonia in fatal cases of influenza Suppurative inflammation; production of pus is the main characteristics eg abscess, peritonitis following rupture of appendix Peritonitis- purulent inflammation CHRONIC INFLAMMATION Chronic inflammation is a long term inflammatory response that can last for months or even years. Its different from acute inflammation, which is the body’s normal response to an injury or infection and resolves over time. Chronic inflammation occurs when the body continues sending out inflammatory cells and substances, even though there is no infection or injury; persistent immune response. Two major characteristic features of chronic inflammation Ongoing tissue destruction Attempt to repaire by fibrosis( with or without cell regeneration) May develop soon after an acute reaction May be insidious in onset causes Persistent infection Some organisms may be difficult to be eradicated. M. tuberculosis- tuberculosis M. leprae-leprosy T. pallidum- syphilis Fungi parasites ii. Persistent indigestible material. Endogenous- necrotic bone, necrotic adipose tissue, calcium and uric acid deposits. Exogenous- silica, asbestos fibers, suture materials. iii. Immune mediated reactions Autoimmune reactions (Rheumatoid arthritis, Systemic lupus erythromatosus(SLE), Hashimoto’s thyroiditis, Chronic autoimmune gastritis) Organ transplant rejections Unregulated immune responses ( inflammatory bowel disease e.g. ulcerative colitis) iv. Hypersensitivity reactions; inappropriate immune response to generally harmless antigen. bronchial asthma hypersensitivity pneumonitis Following acute inflammation; persistent abscess. Predominant cell type in — acute inflammation; neutrophil –chronic inflammation; macrophage Macrophages are a type of wbc of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris and foreign substances. MACROPHAGE IN CHRONIC INFL. Continuous recruitment from blood -blood is most important source of macrophage -Mediated by: TGF &PDGF Proliferation of macrophage at the site of inflammation. Immobilization of macrophage at the site of inflammation. mediated by migration inhibition factor (MIF) secreted by activated T. lymphocytes. Diseases involving chronic inflammation. Autoimmune diseases (e.g. lupus, rheumatoid arthritis) Cardiovascular diseases (e.g. heart disease, high blood pressure) Several cancers Gastrointestinal diseases (e.g., Crohn’s disease, inflammatory bowel disease) Lung diseases (e.g., asthma, chronic obstructive pulmonary disease) Management Eating an anti-inflammatory diet rich in fruits, vegetables and health fats. Regular exercise Managing stress Avoid smoking and excessive alc consumption. Taking medications as described by a healthcare professional. WOUND HEALING Wound healing is a complex, dynamic process that involves a series of overlapping phases to restore

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Female Reproductive System CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Female Reproductive System using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic Components of the Female Reproductive System The female reproductive system: Female Reproductive System Fertilization The female reproductive system consists of the: Egg cells (ova) are produced in the ovaries and travel through the fallopian tubes to the uterus. Structures and Functions of the Female Reproductive System Ovaries Luteinizing hormone stimulates Graafian follicle (matured follicle) and cause ovulation Fallopian tubes The smooth muscles along it propels the ovum towards the uterus Uterus Vagina The functions of the vagina are to receive sperm from the penis during sexual intercourse, External genitals (Vulva) Labia majora and minora Oogenesis This hormone also stimulates the follicle cells to secrete estrogen, which promotes the maturation of the ovum. The other three cells produced are called polar bodies. They have no function, and will simply deteriorate. Menstrual cycle Menstrual phase The average time is 3-6 days 2. Follicular phase Ovulation phase 3. Luteal phase Without progesterone, the endometrium cannot be maintained and begins to slough off in menstruation. Also secreted by the corpus luteum during a cycle are the hormones inhibin and relaxin. Key points Evaluation Structure and Functions of the Female Reproductive System Components of the Female Reproductive System What is female reproductive system? What is fertilization? What are the components of the female reproductive system? The female reproductive system: Made up of the internal and external sex organs that function in human reproduction. Female Reproductive System The female reproductive system is immature at birth and develops to maturity at puberty to be able to produce gametes, and to carry a foetus to full term Fertilization Is the fusion/union of male and female gametes, during sexual reproduction, to form a zygote The female reproductive system consists of the: Paired ovaries Fallopian tubes Single uterus Vagina External genital structures Egg cells (ova) are produced in the ovaries and travel through the fallopian tubes to the uterus. The uterus is the site for the growth of the embryo-foetus Structures and Functions of the Female Reproductive System What are the structures and functions of the female reproductive system? Ovaries The ovaries are a pair of oval structures on either side of the uterus in the pelvic cavity Within an ovary are several hundred thousand primary follicles, which are present at birth. Female Reproductive System Each primary ovarian follicle contains an oocyte, a potential ovum or egg cell. Surrounding the oocyte are the follicle cells, which secrete estrogen. Luteinizing hormone stimulates Graafian follicle (matured follicle) and cause ovulation Ruptured follicle become corpus luteum and begins to secrete progesterone and oestrogen Fallopian tubes There are two fallopian tubes(oviducts) The lateral end of a fallopian tube encloses an ovary, and the medial end opens into the uterus. The smooth muscles along it propels the ovum towards the uterus The ovum is fertilized in the fallopian tube and swept to the uterus Uterus The uterus is shaped like an upside-down pear, superior to the urinary bladder and between the two ovaries in the pelvic cavity Female Reproductive System During pregnancy the uterus increases greatly in size, contains the placenta to nourish the embryo-foetus, and expels the baby at the end of gestation. It is divided in to fundus (upper part), body (central part) and cervix (lower part) Female Reproductive System The myometrium is the smooth muscle layer during pregnancy these cells increase in size to accommodate the growing foetus and contract for labour and delivery at the end of pregnancy. The lining of the uterus is the endometrium, forms the maternal portion of the placenta during pregnancy Vagina The vagina is a muscular tube that extends from the cervix to the vaginal orifice The vaginal opening is usually partially covered by a thin membrane called the hymen which ruptures after sexual intercourse The functions of the vagina are to receive sperm from the penis during sexual intercourse, To provide the exit for menstrual blood flow, and To become the birth canal at the end of pregnancy. External genitals (Vulva) The external female genitalia includes: Clitoris Is a small mass of erectile tissue anterior to the urethral orifice. The only function of the clitoris is sensory. It responds to sexual stimulation. Labia majora and minora Are paired folds of skin which covers the urethra and vagina openings and prevent drying of their mucous membranes Bartholin‘s glands They secrete lubricant which keep the vagina moist during sexual intercourse. Oogenesis How an egg cell is produced? Oogenesis It is the process of meiosis for egg cell formation; it begins in the ovaries and is also regulated by hormones. Follicle stimulating hormone initiates the growth of ovarian follicles, each of which contains an oogonium, a stem cell for egg cell production This hormone also stimulates the follicle cells to secrete estrogen, which promotes the maturation of the ovum. For each primary oocyte that undergoes meiosis, only one functional egg cell is produced. The other three cells produced are called polar bodies. They have no function, and will simply deteriorate. A mature ovarian follicle actually contains the secondary oocyte; the second meiotic division will take place if and when the egg is fertilized. Female Reproductive System The production of ova begins at puberty (10 to 14years of age) and continues until menopause (45 to 55years of age), when the ovaries atrophy and no longer respond to pituitary hormones. Female Reproductive System Note; Oogenesis is the unequal cell division of which produces one to three polar bodies that later degrade, as well as a single haploid ovum, which is produced only if there is penetration of the secondary oocyte by a sperm cell. Menstrual cycle The menstrual cycle includes the activity of the hormones of the ovaries and anterior pituitary gland and the resultant changes in the ovaries (ovarian cycle) and uterus (uterine cycle).

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Epithelial Tissue CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Epithelial Tissue using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic Objectives EPITHELIAL TISSUE It also forms all glands including endocrine and exocrine glands. Classification of Epithelial Tissues Classification based on number of layers (Stratification) Simple Squamous Epithelium Simple Cuboidal Epithelium Simple Columnar Epithelium Stratified squamous epithelium General Functions of Epithelial Tissue Secretion Assignment EPITHELIAL TISSUE Objectives By the end of this session students are expected to be able to: Define Epithelial Tissue Describe the Structure of Epithelial Tissues Classify Epithelial Tissues Explain Functions of Epithelial Tissues EPITHELIAL TISSUE Epithelium is a group of closely associated cells with scanty intercellular materials that cover external and internal surfaces of the body. They form the covering of all body surfaces, line body cavities and hollow organs, and are the major tissue in glands. Epithelial tissues are widely spread throughout the body and are tightly packed together with no intercellular material between the cells or very little intercellular materials. It also forms all glands including endocrine and exocrine glands. The cells are attached to the underlying connective tissue known as the basement membrane. The basement membrane is a connective tissue structure where the epithelial cells are attached. Cells of epithelial tissue appear in different shapes and structure whereas the differences reflect the functions of the epithelium. Classification of Epithelial Tissues Classification according to the cell shape Squamous cells These are flat cells with an irregular flattened shape Cuboidal cells They have a shape similar to a cube, meaning its width is the same size as its height Columnar cells They are taller than they are wide Classification based on number of layers (Stratification) Simple Epithelium Cells are organized in a single layer and therefore all cells are attached to the basement membrane. Because the shapes of the cells include possible function, they are found in different organs depending on their function. There are three types of simple epithelium: 1.Simple squamous epithelium 2.Simple cuboidal epithelium 3.Simple columnar epithelium. Simple Squamous Epithelium All Squamous cells are flat cells with an irregular flattened shape. It is a one-cell layer of simple squamous epithelium. Forms a thin membrane and therefore it is found in places where exchange of material from one compartment to the other occurs. Squamous cells can be found in the heart, blood vessels, lymph vessels and alveoli of the lung. They allow free diffusion. Simple Cuboidal Epithelium This consists of cube-shaped cells fitting closely together lying on a basement membrane. Forms secretory cells, lining of the small ducts of the gland sand it covers the outer surfaces of organs such as the ovaries and in the kidney tubules. Are actively involved in secretion, absorption and excretion. Simple Columnar Epithelium This is formed by a single layer of cells, rectangular in shape lying on a basement membrane. It is found lining the organs of the alimentary tract. Consists of mixture of cells, some absorb the products of digestion and others secrete mucus. Stratified squamous epithelium Consists of several layers of cells of different shapes The cells are arranged into superficial, intermediate and basal (deep) layers. In the deepest layers the cells are mainly columnar and, as they grow towards the surface, they become flattened. It is the main protective epithelium of the body external surface for example in the skin it forms the epidermis. General Functions of Epithelial Tissue Protection Epithelial cells from the skin protect underlying tissue from mechanical injury, harmful chemicals, invading bacteria and from excessive loss of water Sensation Sensory stimuli penetrate specialized epithelial cells Specialized epithelial tissue containing sensory nerve endings is found in the skin, eyes, ears, nose and on the tongue Secretion In glands, epithelial tissue is specialized to secrete specific chemical substances such as enzymes, hormones and lubricating fluids. Absorption Certain epithelial cells lining the small intestine absorb nutrients from the digestion of food. Excretion Epithelial tissues in the kidney excrete waste products from the body and reabsorb needed materials from the urine.Sweat is also excreted from the body by epithelial cells in the sweat glands. Diffusion Simple epithelium promotes the diffusion of gases, liquids and nutrients. Assignment Outline types and functions of epithelial tissues If you fail to plan,you have plan to fail ← PREVIOUS TOPICNEXT TOPIC →VIEW ALL MODULE NOTESVIEW SEMESTER NOTESVIEW ALL LEVEL NOTESALL DIAGNOSTIC RADIOLOGY NOTES Need These Notes as PDF? Need a clean, well-formatted PDF copy for offline study, revision or printing? Request the complete notes directly through WhatsApp. GET WELL-FORMATTED PDF NOTES

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Endocrine System CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Endocrine System using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic Is a biochemical communication network through which several small glands control a broad range of vital body activities. The endocrine glands are: Posterior pituitary gland. Anterior pituitary gland Adrenocorticotropic hormone (ACTH) stimulates the secretion of cortisol and other hormones by the adrenal cortex. Thyroid gland Calcitonin Pancreas Endocrine System Adrenal glands Ovaries Testes Hormones may be The general functions of the endocrine system include: Common Endocrine disorders Radiographic features; Findings of secondary and tertiary hyperparathyroidism includes; Subperiosteal resorption Brown tumor Hyperpituitarism Generalized overgrowth of all the body tissues is the underlying abnormality in acromegaly. Thickened calvarium with pituitary enlargement Acromegaly. Lateral skull projection demonstrating a thickened frontal bone with characteristic frontal bossing Pituitary microadenoma Hypopituitarism Hypothyroidism AP of the pelvis in a child with hypothyroidism (cretinism). Vitamin related bone disease Rickets and osteomalacia liver disease Osteomalacia Radiographic appearance Rickets Causes of Vitamin D deficiency include : Radiographic Features cont…. Scurvy Disorders of the Growth hormone: Disorders of the thyroxine Diabetes Mellitus Type 2 is called non–insulin-dependent diabetes, and its onset is usually later in life (maturity onset). Disorders of the adrenal cortex Cushing’s syndrome ENDOCRINE SYSTEM Is a biochemical communication network through which several small glands control a broad range of vital body activities. The endocrine glands secrete chemical messengers called hormones, which circulate in the blood and may affect a single target organ or the entire body. The endocrine glands are: Pituitary gland Thyroid gland Parathyroid gland Adrenal gland Pancreas Ovaries Testes Pituitary gland It hangs from the hypothalamus and is enclosed by the sphenoid bone. It is divided into posterior pituitary gland and anterior pituitary gland. Posterior pituitary gland. The two hormones of the posterior pituitary gland are produced by the hypothalamus and stored in the posterior pituitary gland until needed These hormones are anti-diuretic hormone (vasopressin) and oxytocin and both are peptides. Antidiuretic hormone increases the reabsorption of water by kidney tubules, which decreases the amount of urine formed. The water is reabsorbed into the blood, so as urinary output is decreased, blood volume is increased, which helps maintain normal blood pressure Oxytocin stimulates contraction of the uterus at the end of pregnancy and stimulates release of milk from the mammary glands. Anterior pituitary gland The hormones produced are regulated by releasing hormone from the hypothalamus. The hormones produced are growth hormones (somatotropin), thyroid stimulating hormone, adrenocorticotropic hormone, prolactin, follicle stimulating hormone and luteinizing hormone. Growth hormones promote growth as increases amino acids transport and protein synthesis. Thyroid stimulating hormone stimulates the normal growth of the thyroid and the secretion of thyroxine (T4) and triiodothyronine (T3). Adrenocorticotropic hormone (ACTH) stimulates the secretion of cortisol and other hormones by the adrenal cortex. Secretion of ACTH is increased by corticotropin-releasing hormone (CRH) from the hypothalamus. Prolactin is responsible for lactation. More precisely, prolactin initiates and maintains milk production by the mammary glands. Follicle stimulating hormone stimulates the growth of ovarian follicles; that is, it initiates egg development in cycles of approximately28 days. Luteinizing hormone is responsible for ovulation, the release of a mature ovum from an ovarian follicle. Thyroid gland The thyroid gland is located on the front and sides of the trachea just below the larynx The structural units of the thyroid gland are thyroid follicles, which produce thyroxine (T4) and triiodothyronine(T3) and iodine is necessary foe production of these hormones Thyroxine and T3 Thyroxine (T4) and T3 have the same functions: regulation of energy production and protein synthesis, which contribute to growth of the body and to normal body functioning throughout life. Thyroxine and T3 increase cell respiration of all food types (carbohydrates, fats, and excess amino acids) and thereby increase energy and heat production. Calcitonin Decreases the reabsorption of calcium and phosphate from the bones to the blood, thereby lowering blood levels of these minerals. This function of calcitonin helps maintain normal blood levels of calcium and phosphate and also helps maintain a stable, strong bone matrix Parathyroid gland They produce a hormone called parathyroid hormone. Parathyroid hormone is an antagonist of calcitonin It increases the reabsorption of calcium and phosphate from bones to the blood, thereby raising their blood levels. And also increase their absorption from the intestine. Pancreas It is located in the upper left quadrant of the abdominal cavity, extending from the curve of the duodenum to the spleen. It is also an exocrine gland. The pancreatic hormones are produced by the cells called islet of Langerhans and the hormones are insulin and glucagon. Endocrine System Glucagon stimulates the liver to change glycogen to glucose (this process is called glycogen lysis, which literally means “glycogen breakdown”) and to increase the use of fats and excess amino acids for energy production. The overall effect of glucagon, therefore, is to raise the blood glucose level and to make all types of food available for energy production and is stimulated by hypoglycaemia. Insulin increases the transport of glucose from the blood into cells by increasing the permeability of cell membranes to glucose. A deficiency of insulin or in its functioning is called diabetes mellitus. Adrenal glands The two adrenal glands are located one on top of each kidney. Each adrenal gland consists of two parts: an inner adrenal medulla and an outer adrenal cortex. The cells of the adrenal medulla secrete epinephrine and norepinephrine, which collectively are called catecholamine sand are sympathomimetic. Epinephrine (Adrenalin) and norepinephrine (noradrenalin) are both secreted in stress situations and help prepare the body for “fight or flight.” Endocrine System The adrenal cortex secretes three types of steroid hormones: mineralocorticoids, glucocorticoids and sex hormones (oestrogens and androgens). Aldosterone is a mineralocorticoid and increases the reabsorption of sodium and the excretion of potassium by the kidney tubules hence maintains normal blood volume and blood pressure. Cortisol is a glucocorticoid and

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Disorders Of Male Reproductive System CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Disorders Of Male Reproductive System using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic By the end of this session students are expected to be able to: Common Disorders of the Male Reproductive System Male reproductive system disorders Explanation of the Common Disorders of the Male Reproductive System Disorders Of Male Reproductive System Erectile Dysfunction Sexually transmitted diseases Key point Evaluation Common Disorders of the Male Reproductive System By the end of this session students are expected to be able to: Define Male Reproductive Disorder List Common Disorders of the Male Reproductive System. Explain the Common Disorders of the Male Reproductive System Common Disorders of the Male Reproductive System What are the common disorders of the male reproductive system? Male reproductive system disorders Its infections that affect the reproductive tract, which is part of the Reproductive System For males these infections are at the penis, testicles, urethra or the vas deferens. The course of these disorders could be bacterium, virus, fungus or other organism. Some infections are easily treatable and can be cured, some are more difficult, and some are non-curable such as AIDS and herpes Common disorders of the male reproductive system Testicular cancer Prostate disorders Prostate cancer Erectile Dysfunction Sexually transmitted diseases Explanation of the Common Disorders of the Male Reproductive System Testicular cancer It is the most common cancer in males between the ages of 20 and 35. An early sign of testicular cancer is a mass in the testis Prostate disorders Because the prostate surrounds part of the urethra, any infection, enlargement (Benign Prostate Hyperplasia), or tumour (Cancer) can obstruct the flow of urine. Disorders Of Male Reproductive System Acute and chronic infections of the prostate are common in postpubescent males, often in association with inflammation of the urethra. Symptoms may include fever, chills, urinary frequency, frequent urination at night, difficulty in urinating, burning or painful urination, low back pain, joint and muscle pain, blood in the urine, or painful ejaculation Prostate cancer Is the leading cause of death from cancer in men Treatment for prostate cancer may involve surgery, cryotherapy, radiation, hormonal therapy, and chemotherapy Erectile Dysfunction Erectile dysfunction (ED), previously termed impotence, is the consistent inability of an adult male to ejaculate or to attain or hold an erection long enough for sexual intercourse. Many cases of impotence are caused by insufficient release of nitric oxide (NO), which relaxes the smooth muscle of the penile arterioles and erectile tissue. Other causes of erectile dysfunction include Diabetes mellitus, physical abnormalities of the penis, Systemic disorders such as syphilis, Vascular disturbances (arterial or venous obstructions), Neurological disorders Surgery Testosterone deficiency Drugs (alcohol, antidepressants, antihistamines, antihypertensive, narcotics, nicotine, and tranquilizers). Psychological factors such as anxiety or depression, fear of causing pregnancy, fear of sexually transmitted diseases Sexually transmitted diseases The sexually transmitted diseases of the male reproductive system already discussed with the sexually transmitted diseases of the female reproductive system Key point The common disorders of the male reproductive system are testicular cancer, prostate disorders, erectile dysfunction and sexually transmitted diseases Erectile dysfunction is a big problem to the society and is caused by a number of factors. Evaluation Define male reproductive disorder List common disorders of the male reproductive system. What is the early sign of testicular cancer? What are the causes of erectile dysfunction? ← PREVIOUS TOPICNEXT TOPIC →VIEW ALL MODULE NOTESVIEW SEMESTER NOTESVIEW ALL LEVEL NOTESALL DIAGNOSTIC RADIOLOGY NOTES Need These Notes as PDF? Need a clean, well-formatted PDF copy for offline study, revision or printing? Request the complete notes directly through WhatsApp. GET WELL-FORMATTED PDF NOTES

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Disorders Of Gi Tract CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Disorders Of Gi Tract using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic Regardless of the cause and type of a disease Gastrointestinal (GI )pathologies have the following presenting features; Abdominal pain Disorders Of Gi Tract Nausea and Vomiting Gastroesophageal Reflux Disease (GERD) Heartburn GI bleeding GI motility disorders Hernia Jaundice DISORDERS OF GI TRACT Regardless of the cause and type of a disease Gastrointestinal (GI )pathologies have the following presenting features; Abdominal pain GI bleeding Diarrhoea Steatorrhea Constipation Nausea Vomiting Dysphagia Odynophagia Gastroesophageal reflux Anorexia Weight loss Abdominal pain Pain originates from tissue injury, distention, contraction, inflammation, and direct chemical injury.Visceral pain is often poorly localized and loosely corresponds to the spinal segment that innervates the involved viscus. Somatoparietal pain arises from noxious stimulation of the parietal peritoneum. Diarrhoea An increased number or fluidity of stools is usually due to an excess of water in stool. Most people have experienced loose stools for a day or two (e.g. viral gastroenteritis), but other causes, such as inflammatory bowel disease, can be chronic and cause intermittent symptoms for a patient's entire lifetime. Disorders Of Gi Tract Diarrhoea results from either an increase in secretion or decrease in absorption or both.It is classified as : secretory or osmotic diarrhoea Bloody diarrhoea occurs with mucosal inflammation or erosions or ulcerations secondary to infectious, inflammatory, or ischemic entero-colitis. Blood in the stool always implies an underlying organic abnormality. Constipation It is characterised by difficult in passage of stool.It occurs most commonly in elderly and often used to describe more than one symptom, including: Infrequent stools A sense of incomplete evacuation Abdominal bloating or discomfort Treatment plans vary, but the simplest and most common starting point is to increase the patient's daily fibre and fluid intake. Nausea and Vomiting Nausea and vomiting may be manifestations of GI diseases or primary non-GI diseases and may lead to fluid and electrolyte imbalances, nutritional deficiencies, aspiration pneumonia and oesophageal rupture Nausea is the unpleasant sensation of the desire to vomit Retching, is coordinated voluntary muscle activity of the abdomen and chest without discharge of stomach contents into the mouth. Vomiting, or the act of emesis, occurs as gastric contents are forcefully ejected out of the mouth Nausea and vomiting may be acute, such as with acute obstruction, inflammation, or ischemia, other acute infections, medication, pregnancy or head trauma. Disorders Of Gi Tract Nausea and vomiting that are chronic in nature are usually associated with pregnancy, medications, and motility disorders such as diabetic, gastroparesis, partial obstruction, intracranial disease, psychogenic disorders, or an underlying metabolic or endocrine disturbance. Dysphagia Is the sensation of solids or liquids not passing from the mouth into the stomach.It is a common symptom and can be divided into: oropharyngeal dysphagia and oesophageal dysphagia. Oesophageal dysphagia is caused by either : Motility disorder, such as achalasia, diffuse oesophageal spasm, or scleroderma. Mechanical obstruction, such as a benign stricture, ring, or neoplasm. Gastroesophageal Reflux Disease (GERD) The terms heartburn, acid regurgitation, sour stomach, and bitter taste are all used to describe GERD symptoms.Reflux occurs when the oesophageal epithelium is exposed to gastric secretions. Some degree of gastric reflux is considered normal, but symptoms occur when the mucosa's tolerance to acid is exceeded. In addition to the typical symptoms of heartburn or chest pain, extra-oesophageal manifestations of GERD include laryngitis, asthma, and chronic cough GERD develops when acidic gastric contents reflux into the oesophagus and remain there long enough to overcome the resistance of the oesophageal epithelium. Heartburn Is typically a burning pain or discomfort that rises up the retro sternum arises from dyspepsia.Dyspepsia refers to persistent or recurrent epigastric pain or meal-related upper abdominal discomfort that may be characterized by early satiation or postprandial fullness Anorexia and Early Satiety Anorexia is loss of the desire to eat and is a major symptom in many GI and non-GI diseases, including central nervous system, systemic, and psychological disorders. Common causes include; Delayed gastric emptying such as occurs in long-term diabetes mellitus Decreased gastric distention secondary to gastric malignancy Gastric outlet obstruction caused by peptic ulcer disease GI bleeding GI bleeding can be either acute or chronic, and it can be massive or occult. Upper GI bleeding may be manifested as Hematemesis(vomiting blood) Lower GI bleeding may be manifested as; 1.Melena (black stool) 2.Haematochezia (Blood in stool) Esophageal varices also lead to upper GI bleeding The two most common causes of acute lower GI bleeding are diverticulosis and arterio-venous malformations. Occult bleeding is defined as the detection of asymptomatic blood loss from the gastrointestinal tract, generally by routine faecal occult blood testing or the presence of iron deficiency anaemia. GI motility disorders Intestinal obstruction Is a blockage that keeps food or liquid from passing through either small intestine or large intestine. There are two main causes of intestinal obstruction,which are; 1.Mechanical obstruction This may be due to extrinsic or intrinsic blockage factors such as Adhesions(Post abd surgery pt),volvulus (twisting of either ceacum or sigmoid colon),intussusception in pediatric patients and fecal impaction. 2.Paralytic ileus This occurs when the muscle of the intestine are paralyzed,preventing peristalsis Hernia Is a defect occurred on a membranous tissue or cavity.It can be congenital or acquired. There are three types of hernia,which are; 1.Reducible hernia 2.Incarcerated hernia 3.Strangulated hernia Other forms of hernia are hiatus,inguinal, Jaundice Is a yellowish discolouration of eye or skin caused by excessive bilirubin(hyperbilirubinemia).Bilirubin is a nitrogenous waste produced after death of red blood cells and is filterd by liver.There are two types of jaundice,which are; 1.Obstructive jaundice, Caused by blockage of biliary tree that lead to poor supply of bile.Bile is stored within Gall bladder 2.Non-obstrucutive jaundice, Caused by poor production of bile due to liver parenchyma diseases ← PREVIOUS TOPICNEXT TOPIC →VIEW ALL MODULE NOTESVIEW SEMESTER NOTESVIEW ALL LEVEL NOTESALL DIAGNOSTIC RADIOLOGY NOTES Need These Notes

DIAGNOSTIC RADIOGRAPHY · NTA LEVEL 4 · SEMESTER ONE Disorders Of Female Reproductive System CRT04101 · Anatomy, Physiology and Pathology START READING NOTES Study Disorders Of Female Reproductive System using the sections below. Use the topic navigation to continue through Anatomy, Physiology and Pathology. Contents of This Topic By the end of this session students are expected to be able to: Definition and Types of Female Reproductive Disorder Female reproductive disorder List common disorders of the female reproductive system. Sexually Transmitted Diseases Common Disorders of the Female Reproductive System Premenstrual syndrome (PMS) Disorders Of Female Reproductive System Getting regular exercise, avoiding caffeine, salt, and alcohol may bring relief Endometriosis Breast cancer Ovarian cancer Cervical cancer Vulvo-vaginal Candidiasis Gonorrhoea In females, infection typically occurs in the vagina, often with a discharge of pus Syphilis Genital Herpes The blisters disappear and reappear in most patients, but the virus itself remains in the body Key points Evaluation Common Disorders of the Female Reproductive System By the end of this session students are expected to be able to: Define Female Reproductive Disorder List Common Disorders of the Female Reproductive System. Explain the Common Disorders of the Female Reproductive System Definition and Types of Female Reproductive Disorder What are the female reproductive disorder Female reproductive disorder Its infections that affect the reproductive tract which is part of the Reproductive System. Reproductive tract infections can be in either the upper reproductive tract (fallopian tubes, ovary and uterus), and the lower reproductive tract (vagina, cervix and vulva) List common disorders of the female reproductive system. Premenstrual syndrome (PMS) Premenstrual dysphoric disorder (PMDD) Endometriosis Breast cancer Ovarian cancer Cervical cancer Vulvovaginal Candidiasis Sexually Transmitted Diseases Gonorrhoea Syphilis Genital Herpes Genital Warts Common Disorders of the Female Reproductive System What are common disorders of the female reproductive system? Premenstrual syndrome (PMS) It is a cyclical disorder of severe physical and emotional distress. Disorders Of Female Reproductive System It may be presented by oedema, weight gain, breast swelling and tenderness, abdominal distension, backache, joint pain, constipation, skin eruptions, fatigue and lethargy, greater need for sleep, depression or anxiety Getting regular exercise, avoiding caffeine, salt, and alcohol may bring relief Premenstrual dysphoric disorder (PMDD) It is a more severe syndrome in which PMS-like signs and symptoms do not resolve after the onset of menstruation. Endometriosis Is characterized by the growth of endometrial tissue outside the uterus. It can cause inflammation, pain, scarring, and infertility. Symptoms include premenstrual pain or unusually severe menstrual pain. Breast cancer Generally is not painful until it becomes quite advanced Any lump, no matter how small, should be reported to a physician at once Disorders Of Female Reproductive System Among the factors that increase the risk of developing breast cancer is a family history of breast cancer, null parity (never having borne a child) or having a first child after age 35, previous cancer in one breast, exposure to ionizing radiation, such as x-rays, excessive alcohol intake and cigarette smoking. Ovarian cancer Risk factors associated with ovarian cancer include age (over age 50), race (whites are at highest risk), family history of ovarian cancer, more than 40 years of active ovulation, null parity, a high-fat and low-fibre Cervical cancer Starts with cervical dysplasia; a change in the shape, growth, and number of cervical cells. The cells may either return to normal or progress to cancer. Increased risk is associated with having a large number of sexual partners, having first intercourse at a young age and smoking cigarettes. Vulvo-vaginal Candidiasis Candida albicans commonly grows on mucous membranes of the gastrointestinal and genitourinary tracts. It is the most common form of vaginitis inflammation of the vagina. Candidiasis is characterized by severe itching, a thick, yellow and cheesy discharge, a yeasty odour and pain. Sexually Transmitted Diseases A sexually transmitted disease (STD) is one that is spread by sexual contact. It is in both male and female reproductive systems Chlamydia Is a sexually transmitted disease caused by the bacterium Chlamydia trachomatis Disorders Of Female Reproductive System In males, urethritis is the principal result, causing a clear discharge, burning on urination, frequent urination, and painful urination. In 70% of females with chlamydia, symptoms are absent, but chlamydia is the leading cause of pelvic inflammatory disease. Gonorrhoea Gonorrhoea is caused by the bacterium Neisseria gonorrhoeae. Males usually experience urethritis with profuse pus drainage and painful urination. Complication: salpingitis can cause infertility In females, infection typically occurs in the vagina, often with a discharge of pus Up to 50% of infected females may harbour the disease without any symptoms Syphilis Syphilis, caused by the bacterium Treponema pallidum, is transmitted through sexual contact or exchange of blood, or through the placenta to a foetus. Disorders Of Female Reproductive System In primary stage, there may be a painless sores called chancre and a signs and symptoms such as a skin rash, fever, and aches in the joints and muscles usher in the secondary stage Genital Herpes Genital herpes is an incurable STD. Type II herpes simplex virus causes genital infections, producing painful blisters on the prepuce, glans penis, and penile shaft in males and on the vulva or sometimes high up in the vagina in females. The blisters disappear and reappear in most patients, but the virus itself remains in the body Genital Warts Warts are an infectious disease caused by viruses. Human papillomavirus (HPV) causes genital warts, which is commonly transmitted sexually. Disorders Of Female Reproductive System Patients with a history of genital warts may be at increased risk for cancers of the cervix, vagina, anus, vulva, and penis. There is no cure for genital warts. Key points Severe physical and emotional distress can cause premenstrual syndrome. Cigarette smoking and excess alcohol taking are the main causes of many cancers including those of the female reproductive system. child bearing at older age, earlier sexual intercourse and multiple partners as may cause cancers of the female reproductive system. Evaluation Define female reproductive disorder List common disorders of the female reproductive system. What are the