Gelatin Capsules: Capsule Evaluation, Packing and Storage (Part 5)
Explore “Capsule Evaluation, Packing and Storage” in this Gelatin Capsules lesson. Part 5 of the five-part series brings together the source material and lesson topics. Use the contents links to find a section, read the notes, and consult the complete original teaching slides below.
Lesson topics
- EVALUTION OF CAPSULES:
- Weight variation test:
- Dissolution test for capsules:
- PACKING & STORAGE OF CAPSULES:
Contents
- Read the original document
- EVALUTION OF CAPSULES:
- Weight variation test:
- Dissolution test for capsules:
- PACKING & STORAGE OF CAPSULES:
REQUEST THE COMPLETE DOCUMENT ON WHATSAPP
Read the original source document
Capsules – Naresh Gorantla: original teaching slides for this study series.
EVALUTION OF CAPSULES:
EVALUTION OF CAPSULES: (1) Weight variation test (2) Content uniformity (3) Disintegration test (4)Dissolution test (5)Moisture permeation test
Weight variation test:
Weight variation test: 20 capsules are taken at random and weighed. Their average weight is calculated, then each capsule is weighed individually and their weight is noted. The capsule passes the test if the weight of individual capsule falls with in 90-110% of the average weight.
Dissolution test for capsules:
Dissolution test for capsules: Place 1000ml of water having a temp. of 36.5º to 37.5º into the vessel. Place specified number of capsules in basket & adjust the speed to 100 rpm. Withdraw req. volume for every 10min time interval. Filter and determine the amount of active ingredient. The sample passes the test if the amount of active ingredients in the solution is not less than 70% of the stated amount.
PACKING & STORAGE OF CAPSULES:
PACKING & STORAGE OF CAPSULES: Capsules should be packed well closed glass & plastic container & stored at temp. not exceeding 30ºc. Capsules are individually protected by enclosing in strip & blister packaging. In strip packing the capsule is hermetically sealed within the strips of an aluminum or plastic film. In blister packs, a press on the blister forces the capsule through the backing strip.
Capsules have a larger shelf life in unopened glass bottles than in strip pack & but this is reversed.
Review questions and answers
What are the key points about EVALUTION OF CAPSULES:?
EVALUTION OF CAPSULES: (1) Weight variation test (2) Content uniformity (3) Disintegration test (4)Dissolution test (5)Moisture permeation test
What are the key points about Weight variation test:?
Weight variation test: 20 capsules are taken at random and weighed. Their average weight is calculated, then each capsule is weighed individually and their weight is noted. The capsule passes the test if the weight of individual capsule falls with in 90-110% of the average weight.
What are the key points about Dissolution test for capsules:?
Dissolution test for capsules: Place 1000ml of water having a temp. of 36.5º to 37.5º into the vessel. Place specified number of capsules in basket & adjust the speed to 100 rpm. Withdraw req. volume for every 10min time interval. Filter and determine the amount of active ingredient. The sample passes the test if the amount of active ingredients in the…
What are the key points about PACKING & STORAGE OF CAPSULES:?
PACKING & STORAGE OF CAPSULES: Capsules should be packed well closed glass & plastic container & stored at temp. not exceeding 30ºc. Capsules are individually protected by enclosing in strip & blister packaging. In strip packing the capsule is hermetically sealed within the strips of an aluminum or plastic film. In blister packs, a press on the blister…
More lessons from this document
- Capsules – Naresh Gorantla — Part 1
- Capsules – Naresh Gorantla — Part 2
- Capsules – Naresh Gorantla — Part 3
- Capsules – Naresh Gorantla — Part 4
- Capsules – Naresh Gorantla — Part 5
Conclusion
The important points in Important Concepts should be reviewed alongside the definitions, examples and comparisons given above. Continue with the other four articles to cover the rest of the source material.