Description of Fluoroquinolone Drugs
Session 7: Description of Fluoroquinolone Drugs
Total Session Time: 120 minutes
Prerequisites
Learning Tasks
By the end of this session students are expected to be able to:
Resources Needed:
SESSION OVERVIEW
Activity/
Step Time Content
Method
1 05 minutes Presentation Introduction, Learning tasks
Presentation/ Indications of Fluoroquinolone
2 20 minutes
Buzzing Drugs
Presentation/ Contraindication of Fluoroquinolone
3 20 minutes
brainstorming Drugs
4 30 minutes Presentation Dose, Dosage and Course of Fluoroquinolone
Drugs
Presentation/ Side Effects and Adverse Effects of
5 20 minutes
brainstorming Fluoroquinolone Drugs
Interaction and Precaution of Fluoroquinolone
6 15 minutes Presentation
Drugs
7 05 minutes Presentation Key Points
8 05 minutes Presentation Evaluation
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SESSION CONTENTS
STEP 1: Presentation of Session Title and Learning tasks (5 minutes)
READ or ASK students to read the learning tasks and clarify
ASK students if they have any questions before continuing.
STEP 2: Indications of Fluoroquinolone Drugs (20minutes)
Activity: Buzzing (5 minutes)
Ask students to pair up and buzz on the following questions:
ALLOW few pairs to respond
WRITE their responses on the flip chart/ board
CLARIFY and SUMMARISE by using the content below
levofloxacin
selectivity for targets that are either unique to microorganisms or much more important in
them than in humans
particularly active against Gram-negative bacteria, including salmonella,
shigella,campylobacter, neisseria, and pseudomonas
Streptococcus pneumoniae and Enterococcusfaecalis; it should not be used for
pneumococcal pneumonia.It is active against chlamydia and some Mycobacteria
gonorrhoea, and non-gonococcalurethritis and cervicitis
o It has greater activity against pneumococci than ciprofloxacin.
o Levofloxacin is licensed for community-acquired pneumonia but it is considered to be
second-line treatment for this indication
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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STEP 3: Contraindication of Fluoroquinolones Drugs (20 minutes)
Activity: brainstorming (5 minutes)
ASK learners to brainstorm on the following question
ALLOW few students to respond
WRITE their responses on the flipchart
CLARIFY and SUMMARISE by using the content below
Fluoroquinolones are contraindicated in:
STEP 4: Dose, Dosage and Course of Fluoroquinolone drugs (30 minutes)
in pseudomonal lower respiratory-tract infection in cystic fibrosis)
usually adequate for acute uncomplicated cystitis in women)
or deep-seated infection
o Prophylaxis of meningococcal meningitis by intravenous infusion over 60 minutes,
o Anthrax (treatment and post-exposure prophylaxis, every 8–12 hours
infection)
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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STEP 4: Side Effects and Adverse Effects of Fluoroquinolone Drugs
(20minutes)
ACTIVITY: brainstorming (5 minutes)
ASK students to brainstorm on the following question
ALLOW few students to respond
WRITE their responses on the flipchart
CLARIFY and SUMMARISE by using the content below
Adverse effects and side effects of Fluoroquinolones
develop
growing cartilage and cause an arthropathy
STEP 5: Interactions and Precautions of Essential Fluoroquinolone Drugs
(15 minutes)
o Also should avoided in those receiving quinidin procainamide sotalol, ibutilide,
amiodarone)
o Patients receiving other agent like erythromycin, tricyclic antidepressants should be
given fluoroquinolones with caution
Quinolones should be used with caution in:
o Patients with a history of epilepsy or conditions that
o Renal impairment
o Pregnancy
o During breast-feeding
o Quinolones may induce convulsions in patients with without a history of convulsions
o Should be used with caution in condition that predispose to seizures and myasthenia
gravis
o Taking nsaids at the same time may also induce them
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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Step 7: Key Points (5minutes)
ciprofloxacin, oxfloxacin and levofloxacin
related to Fluoroquinolones use, patient with hepatic impairment and in pregnancy
STEP 8: Evaluation (5minutes)
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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References
Pharmacotherapy: A Pathophysiologic Approach (9th ed.). New York, McGraw-Hill
Education.
Ministry of Health and Social Welfare. (2013). Standard Treatment Guidelines & National
Essential Medicines List Tanzania Mainland (4th ed.). Dar es salaam, Tanzania
government printers.
Sally S.R & Jeanne C.S. (2000). Introductory Clinical Pharmacology (6th ed) New York,
Lippincott Williams and Wilkins
School of Pharmaceutical sciences. (2011).Tanzania Pharmaceutical Handbook (2nd ed.).
Dar es Salaam, ARDHI University press.
The Royal Pharmaceutical Society of Great Britain. (2007). Martindale, the Extra
Pharmacopoeia (5TH ed). London, pharmaceutical press.
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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