Description of Macrolide Drugs
Session 5: Description of Macrolide Drugs
Total Session Time: 60 minutes
Prerequisites
Learning Tasks
By the end of this session students are expected to be able to:
Resources Needed:
SESSION OVERVIEW
Activity/
Step Time Content
Method
1 05 minutes Presentation Introduction, Learning Tasks
Presentation/
2 10 minutes Indications of Macrolide Drugs
Buzzing
Presentation/
3 10 minutes Contraindications of MacrolideDrugs
brainstorming
The dose, Dosage and Course of Macrolide
4 10minutes Presentation
Macrolide Drugs
Presentation/ The Side Effects and Adverse Effects of
5 10 minutes
brainstorming Macrolide Drugs
Interactions and Precautions of Macrolide
6 05minutes Presentation
Drugs
7 05 minutes Presentation Key Points
8 05 minutes Presentation Evaluation
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SESSION CONTENTS
STEP1: Presentation of Session Title and Learning tasks (5 minutes)
READ or ASK students to read the learning tasks and clarify
ASK students if they have any questions before continuing.
STEP 2: Indications of Macrolide Drugs (10minutes)
Activity: Buzzing (5 minutes)
ASK students to pair up and buzz on the following question for 2 minutes
ALLOW few pairs to respond and let other pairs to add on points not mentioned
WRITE their response on the flip chart/board
CLARIFY and SUMMARIZEby using the content below
o Erythromycin
o Clarithromycin
o Azithromycin
o Are effective against gram-positive organisms, especially pneumococci, streptococci,
staphylococci, and corynebacteria
o Also effective to Mycoplasma, legionella, Chlamydia trachomatis, Chlamydia
psittaci, Chlamydia pneumoniae, helicobacter, listeria, and certain mycobacteria
(Mycobacterium kansasii, M scrofulaceum)
o Gram-negative organisms such as Neisseria sp, Bordetella pertussis, Bartonella
henselae, and B quintana (etiologic agents of cat-scratch disease and bacillary
angiomatosis) some rickettsia sp, Treponema pallidum, and campylobacter sp are
susceptible.
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STEP 3: Contraindication of Macrolide Drugs (10minutes)
Activity: Brainstorming (5 minutes)
Ask students to brainstorm on the following question:
ALLOW few students to respond
WRITE their responses on the flip chart/ board
CLARIFY and SUMMARISE by using the content below
o In patient with hepatic impairment
o In patient with Renal impairment
o Pregnancy
o Hepatic dysfunction
o Renal impairment
o Breastfeeding
o Pregnancy
o Hepatic dysfunction
o Renal impairment
STEP 4: Dose, Dosage and Course of Macrolide drugs (10minutes)
o The oral dosage of erythromycin base is250-500mg every 6 hours (for children, 40
o Over 8 years 250-500mg every six hoursOr 4000mg daily in divided doses in severe
infection
o The dosage of erythromycin ethylsuccinate is 400-600mg every 6 hours
kanamycin for preoperative preparation of the colon
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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o 500mg once daily for 3three days
o 500mg on the firstday then250mg once daily for 4 days
o 250mg every 12 hours for seven days
o In severe infections 500mg 12hourly for 14 days
o Intravenously infusion 500mg twice daily
STEP 5:Side Effects and Adverse Effects of Macrolide Drugs(10 minutes)
Activity: Brainstorming (5 minutes)
Ask students to brainstorm on the following question:
ALLOW few students to respond
WRITE their responses on the flip chart/ board
CLARIFY and SUMMARISE by using the content below
The following are the side effects/adverse effects of macrolides drugs:
STEP 6: Interaction and Precaution of Essential Macrolide drugs(5min)
o Erythromycin metabolites can inhibit cytochrome P450 enzymes
thus increase the serum concentrations of theophylline, oral anticoagulants,
cyclosporine, and methylprednisolone
o Erythromycin increases serum concentrations of oral digoxin by increasing its
bioavailability
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Step 7: Key Points (5 minutes)
streptococci, staphylococci, and corynebacteria
Diarrhoeadiarrhoea
STEP 8: Evaluation (5 minutes)
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References
Pharmacotherapy: a pathophysiologic approach (9thed.). New York, McGraw-Hill
Education.
Ministry Of Health and Social Welfare. ( 2013). Standard Treatment Guidelines & National
Essential Medicines List Tanzania Mainland (4th ed.). Dar es salaam, Tanzania
government printers.
Sally, S.R&Jeanne C.S. (2000). Introductory Clinical Pharmacology (6thed) New York,
Lippincott Williams and Wilkins
School of Pharmaceutical sciences.( 2011).Tanzania Pharmaceutical Handbook(2nd ed.). Dar
es Salaam, ARDHI University press.
The Royal Pharmaceutical Society of Great Britain. (2007). Martindale, the Extra
Pharmacopoeia (5THed). London, pharmaceutical press.
The Royal Pharmaceutical Society of Great Britain. (2009). British National Formulary (59th
ed). London, BMJ Group and RPS Publishing.
PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide
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