Cultivation of medicinal plants – PST05210 Basic Pharmacognosy

NTA Level 5 • Semester 2 • PST05210

Cultivation of medicinal plants

Basic Pharmacognosy • Source Session/Topic 12
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 12: Cultivation of medicinal plants

Total Session Time: 120 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• Classify medicinal plants
• Explain the cultivation of medicinal plants
• List factors affecting cultivation of medicinal plants
• Explain the importance of plant as a major source of drugs
• List available plants commonly used as source of drugs in Tanzania

Resources Needed:

• Flip charts, marker pens, and masking tape
• Black/white board and chalk/whiteboard markers
• LCD projector and laptop

SESSION OVERVIEW

|Step |Time |Activity/ |Content |

| | |Method | |

|1 |05 minutes |Presentation |Introduction, Learning Tasks |

|2 |20 minutes |Presentation |Classification of Medicinal Plants|

| | |Buzzing | |

|3 |30 minutes |Presentation |Cultivation of Medicinal Plants |

| | |Brainstorming | |

|4 | | |Factors Affecting Cultivation of |

| |25 minutes |Presentation |Medicinal Plants |

|5 |20 minutes |Presentation |Plant Breeding Methods |

|6 |05 minutes |Presentation |Key Points |

|7 |05 minutes |Presentation |Evaluation |

|8 |10minutes |Presentation |Assignment |

SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning objectives and clarify

ASK students if they have any questions before continuing.

STEP 2: Classification and Nomenclature of Medicinal Plants (20 minutes)

• Classification of medicinal plants

o Alphabetical Classification

▪ This classification employs the use of either Latin or Vernacular

names of the medicinal plant

▪ This method is simple and suitable for quick reference
▪ Disadvantageously, this method does not give indication of

interrelationships between drugs e.g. in Pharmacopoeias

o Taxonomic Classification

▪ This method is based on botanical classification
▪ Drugs are arranged according to the plants from which they

are obtained

▪ Drugs are grouped into families, Classes, orders, genera and

species

o Morphological Classification

▪ Physical features of the drugs are used in the

classification

• Organized drugs

o For instance, leaves, flowers, fruits, seeds, wood, barks,

rhizomes & roots

• Unorganized drugs

o For instance, dried lattices, extracts, gums, resins, oils, fats and

waxes

o Pharmacological or therapeutic Classification

▪ Drugs are classified according to pharmacological actions of their

most important constituents or their therapeutic uses, e.g.

cardiotonic drugs, CNS stimulants, Muscle relaxants, etc.

o Chemical or Biogenetic Classification

▪ Drugs are classified according to their important constituents

e.g. alkaloids, glycosides, volatile oils

▪ They are also classified based on their biosynthetic pathways
• Nomenclature in Medicinal Plants

o The binomial system founded by the Swedish biologist Linnaeus is used

o The first name (genus name) starts with a capital letter and the

second name (species) begins with a small letter

o Genus and species names may be followed by author’s name who first

described the species or variety. e.g. Artemisia cina Berg.,

Caryophyllos aromaticus L

o Sometimes, species name is derived from author’s name, e.g. Cinchona

Ledgeriana after Charles Ledger

o The species name usually indicates certain characteristics of the

plant e.g.

▪ Cassia acutifolia means “sharp pointed leaflets”
▪ Atropa belladonna (bella= beautiful, donna=lady)
▪ Piper nigrum (black)
▪ Myristica fragrans (nice aroma)
▪ Hydrastis Canadensis (growing in Canada)
▪ Papaver sominferum (inducing sleep)

o The generic name may indicate certain characters of the plant e.g.

▪ Glycyrrhiza means gluco = sweet, riza = root,

STEP 3: Cultivation of Medicinal Plants (30 minutes)

• Drugs may be collected from wild or cultivated plants
• Collection may be done by skilled or unskilled labour
• Collection from cultivated sources ensure sustainability of medicinal

plants

• In some cases, pharmacopoeias specify cultivated species such as Fennel,

ginger, cinnamon and opium

• Disadvantages of Wild Plant Collection

o Sparse distribution e.g. Sceletium tortuosum. Potentially difficult to

transport plant to area of processing

o Difficult access (e.g. forests, mountains etch)

o Collector ignorance leads to admixture of other plants, collection of

undesired plant parts or stage of development or during an incorrect

season ( loss of medicinal activity.

o Damage to natural environment which leads to extinction of a species.

|Activity: Brainstorming (5 minutes) |

| |

|Ask students to brainstorm on the following question: |

| |

|What are the advantages of cultivation of medicinal plants? |

| |

|ALLOW few students to respond? |

| |

|WRITE their responses on the flip chart/ board |

| |

|CLARIFY and SUMMARISE by using the content below |

• Advantages of Cultivated Medicinal Plants

o Only desired species are collected therefore uniform quality.

o Collection, transport and access to processing facilities is improved.

o Better control of soil quality, pests and plant disease.

o Supply: Constant and Regular (Controlled)

o Collectors are trained

STEP 4: Factors Affecting Cultivation of Medicinal Plants (25 minutes)

• Environmental (Exogenous) Factors

o Temperature

▪ It is a major factor that affects both the growth/development and

metabolism of the plants

▪ Each plant is specialized to adapt to its native environment
▪ But most plants are able to exist in wide temperature ranges e.g.

Tropical and Sub-tropical plants in temperate regions

▪ Temperature affects plant chemical reaction rates
• e.g. Datura stramonium produces lower alkaloids in cloudy/rainy

weather (winter)

• Volatile oils are produced more readily in warmer weather

o Very hot days lead to a physical loss of oil

• Growing peppermint in shade rather than the sun.

o Rainfall

▪ Annual rainfall, distribution, humidity effect medicinal

plants

▪ Rainfall influences the production of glandular hairs
▪ Continuous rainfall may lead to loss of water-soluble

substances such as glycosides, tannins, flavonoids and some

volatile oils through leaves and roots

o Day-length (sunlight)

▪ Amount and intensity of light needed differs from plant to

plant

▪ Amount of glycosides, alkaloids and volatile oils produced

are greatly affected by amount of sunlight

• Long day: menthone, menthol and menthofuran traces
• Short day: menthofuran is a main component
▪ Belladonna, Stramonium and Cinchona ledgeriana full sunshine

gives high content of alkaloids than does shade

▪ Other species: produce more active constituents at night

e.g. Nicotiana

o Radiation

▪ Type of radiation plants receive e.g. Ocimum basilicum –

plants grown in glass houses have less phenols and terpenoids

in the leaves (flavonoids, volatile oils)

o Latitude and Altitude

▪ Gentian produce bitter constituents when grown in higher

altitude

▪ Thyme and Peppermint produce less constituents when grown in

higher altitude

▪ Coconut needs a maritime climate
▪ Sugar cane is lowland plant
▪ Tragacanth, Cinchona succirubra require elevation
▪ Tea requires (1000-2000 M), coffee (800 – 1800 M), and cocoa

(100 – 200 M)

▪ Peanut & olive grown in the subtropics produce a higher

unsaturated fat content.

o Soil Condition

▪ Soil character, composition, permeability, porosity all

effect growth of medicinal plants e.g.

• Chalky soil lead to poor of Digitalis
• Crop rotation improves nutrient content of soils
• pH of soil affects inorganic compounds of soil
• Genetic (Endogenous) Factors

o Allelopathy

▪ Allelopathy is the constant effect which living organisms exert on

each other, which may be either beneficial or harmful

▪ Different plants growing together affect each other in terms

of:

• Germination rate
• Leaf development
• Fruit maturation
• Chemical constituents produced
▪ It is transmitted between plants in a number of ways
• Exhalation of leaves
• Root secretions
• Extractions from fallen leaves into the soil

o Mutual dependant organisms (beneficial) symbiosis e.g. Urtica

dioica

o Destructive allelopathy antibiosis e.g. Belladonna growth is

inhibited when cultivated next to mustard

• Post-Cultivation Factors

o Drying & storage methods of drugs

STEP 5: Plant Breeding Methods (20 minutes)

• Plant breeding methods;

o Selection

o Hybridization

o Transgenic medicinal plants

• Selective Breeding

o Individual plants showing the most desirable characteristics are chosen

and interbred

o Second population has improved quality

• Advantages of Selective Breeding

o Improved growth rate, ]

o Disease resistance

o Winter hardiness

o Increased yield of medicinal actives

• Hybridisation

o Mating of different species or varieties to produce a hybrid progeny,

different from both parents (incorporating desired characteristics).

E.g. Mentha piperita and M. spicata are naturally occurring hybrids

• Transgenic Medicinal Plants

o Genetic Engineering: Recombinant DNA

▪ Transfer DNA sequences from the chromosomes of 1 plant to

another

▪ Lead to the artificial transfer of a particular character

from one organism to another

• Plant Propagation

o Seed

▪ In digitalis for instance, treatment of seed prior to sowing may

influence germination, higher plants need soaking before germination

(water/acid)

o Vegetatively

▪ Includes bulb, tuber, rhizome

o By division

▪ plant separated from aerial stems/buds, each with roots and growing

point

o Runners

▪ mint

o Stolons

▪ Liquorice

o Cuttings

▪ Pieces of stem are used

o Grafting

o Fermentation

o Inoculation

o Cell culture

STEP 6 Key Points (5 minutes)

• Correct cultivation and harvesting is aimed at producing high quality

medicinal plants

• General plant breeding methods include selection, hybridization and

transgenic medicinal plants

• Cultivation of medicinal plants is affected by environmental, genetic and

post-collection factors

STEP 7: Evaluation (5 minutes)

• What are the factors affecting cultivation of medicinal plants?
• What are the advantages of cultivation of medicinal plants?
• What are the factors of variation of active ingredients?

STEP 8: Assignment (10 minutes)

|Activity: Take home Assignment (10 minutes) |

| |

|DIVIDE students in groups or individual. |

| |

|ASK the students to work on the following assignment |

| |

|Explain the importance of plant as a major source of drugs |

|ALLOCATE time for students to do the assignment and submit |

| |

|REFER students to recommended references |

References

Trease, G. E., Evans, W. C., & Evans, D. (2009). Trease and Evans

pharmacognosy. London: Saunders.

Joanne Barnes et al (2002), Herbal medicines 3rd Edition: Pharmaceutical

Press

Wallis, T. E. (2005). Textbook of pharmacognosy. New Delhi: CBS.

Robbers, J. E., Speedie, M. K., Tyler, V. E., & Tyler, V. E. (1996).

Pharmacognosy and pharmacobiotechnology. Baltimore: Williams &

Wilkins.

Heinrich, M., Kinghorn, A. D., Maizels, D., Gibbons, S., & Phillipson, J.

D. (2012). Fundamentals of pharmacognosy and phytotherapy. Edinburgh:

Churchill Livingstone/Elsevier.

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