Structure, Functions and Common Disorders of Lymphatic System – PST04103 Human Anatomy and Physiology

NTA Level 4 • Semester 1 • PST04103

Structure, Functions and Common Disorders of Lymphatic System

Human Anatomy and Physiology • Source Session/Topic 37
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 37: Structure, Functions and Common Disorders of Lymphatic System

Total Session Time: 120 minutes+ 60 minutes assignment

Prerequisites

• None

Students Learning Tasks

By the end of this session students are expected to be able to:

• Define Lymphatic System
• Explain the Organization of Lymphatic System
• Explain the Structures Lymphatic System
• Describe Functions of Lymph System
• List the Common Disorders of the Lymphatic System

Resources Needed:

• Flip charts, marker pens, and masking tape
• Black/white board, chalk and whiteboard markers
• Projector
• Computer

SESSION OVERVIEW

|Step |Time |Activity/ |Content |

| | |Method | |

|1 |05 minutes |Presentation |Introduction, Learning Tasks |

|2 |30 minutes |Presentation |Definition and Organization of |

| | |Brainstorming |Lymphatic System |

|3 | |Presentation |Structures of the Lymphatic System |

| |25 minutes |Small Group | |

| | |Discussion | |

|4 |20 minutes |Presentation |Functions of the Lymphatic System |

| | |Buzzing | |

|5 |20 minutes |Presentation |Common Disorders of the Lymphatic |

| | |Brainstorming |System |

|6 |05 minutes |Presentation |Key Points |

| 7 |05 minutes |Presentation |Evaluation |

|8 |10 minutes |Presentation |Take home assignment |

SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning tasks and clarify

ASK students if they have any questions before continuing

STEP 2: Definition and Organization of Lymphatic System (30minutes)

|Activity: Brainstorming (5 minutes) |

| |

|Ask students to brainstorm on the following question: |

| |

|What is lymphatic system? |

| |

|ALLOW few students to respond |

| |

|WRITE their responses on the flip chart/ board |

| |

|CLARIFY and SUMMARISE by using the content below |

• Lymphatic system: A network of tissue, organs, and vessels that help to

maintain the body’s fluid balance, cleanse the body fluid of foreign

matter and provide immune cells for defence.

• Composition of Lymphatic System

o Lymph, the fluid that the system collects from the interstitial spaces

of the tissue and returns to the bloodstream.

o Lymphatic plexuses, networks of small lymphatic vessels, lymphatic

capillaries, that originate in the extracellular spaces of most

tissues.

o Lymphatic vessels (lymphatics), a nearly body wide network of thin-

walled vessels with abundant valves, originating from lymphatic

plexuses along which lymph nodes are located.

o Lymph nodes, small masses of lymphatic tissue through which lymph is

filtered on its way to the venous system.

o Lymphocytes, circulating cells of the immune system that react against

foreign materials.

o Lymphoid tissue, sites that produce lymphocytes, such as that found in

the walls of the digestive tract; in the spleen, thymus, and lymph

nodes; and in myeloid tissue in red bone marrow.

o The lymphoid tissue is primarily involved in immune responses, and

consists of lymphocytes and other white blood cells enmeshed in

connective tissue through which the lymph passes.

o The lymphatic system differs from the circulatory system in that the

lymphatic do not form a closed ring or circuit.

o Instead, begin blindly in the intercellular spaces of the soft tissues

of the body.

o Specialized lymphatic organs are the tonsils, thymus, and spleen.

[pic]

Source: Tortora, G.J (2009). Figure 35.1: The

lymphatic system

STEP 3: Structures of Lymphatic System (25 minutes)

|Activity: Small Group Discussion ( 30 minutes) |

| |

|DIVIDE students into small manageable groups |

| |

|ASK students to discuss on the following question |

|What are the structures of lymphatic system? |

| |

|ALLOW students to discuss for 15 minutes |

| |

|ALLOW few groups to present and the rest to add points not mentioned |

| |

|CLARIFY and SUMMARIZE by using the contents below |

• The organs of the lymphatic system are tonsils, thymus and spleen.
• Tonsils

o Masses of lymphoid tissue located in a protective ring under mucous

membranes in the mouth and back of the throat.

o Help protect against bacteria that may invade tissues in the area

around the openings between the oral and nasal cavities.

o They are:

▪ Palatine tonsils; located on each side of the throat.
▪ Pharyngeal tonsils; are near the posterior openings of the nasal

cavity.

▪ Lingual tonsils; located near the base of the tongue

o The tonsils serve as the first line of defence from the exterior and

as such are subject to chronic infection (tonsillitis).

• Thymus

o The thymus is located inferior to the thyroid gland.

o In the foetus and infant, the thymus is large and extends under the

sternum

o The thymus hormones are necessary for immunological competence by

enabling the T-cells to participate in the recognition of foreign

antigens and provide immunity.

o This capability of T cells is established early in life and then is

perpetuated by the lymphocytes themselves.

o The new-born’s immune system is not yet fully mature, and infants are

more susceptible to certain infections than are older children and

adults.

o Usually by the age of 2 years, the immune system matures and becomes

fully functional.

• Spleen

o Spleen is located in the left hypochondrium directly below the

diaphragm, above the left kidney and descending colon, and behind the

fundus of the stomach

o It is roughly ovoid

o Is surrounded by a fibrous capsule with inward extensions that

roughly divide the organ into compartments

o Arteries leading into each compartment are surrounded by dense masses

(nodules) of developing lymphocytes

o Near the outer regions of each compartment is tissue called red pulp

made up of fine reticular fibres submerged in blood that comes from

nearby arteries.

o After passing through the reticular meshwork, blood collects in

venous sinuses and then returns to the heart through veins.

STEP 4: Functions of Lymph System (20 minutes)

|Activity: Buzzing (5 minutes) |

| |

|ASK students to pair up and buzz on the following question for 2 |

|minutes |

| |

|What are the functions of lymphatic system? |

|ALLOW few pairs to respond and let other pairs to add on points not |

|mentioned |

| |

|WRITE their response on the flip chart/board |

| |

|CLARIFY and SUMMARIZE by using the content below |

• Lymphatic system plays a critical role in homeostasis.
• Importance of the lymphatic system are

o Maintenance of fluid balance in the internal environment

o Immunity

• The high degree of lymphatic capillary permeability permits large

molecular weight substances which cannot be absorbed by the blood

capillary to be removed from the interstitial spaces.

• Proteins that accumulate in the interstitial spaces can return to the

blood only via lymphatic vessels.

• Absorption and transport of dietary fat, in which special lymphatic

capillaries (lacteals) receive all absorbed fat (chyle) from the

intestine and convey it through the thoracic duct to the venous system.

• Formation of a defence mechanism for the body.
• When foreign protein drains from an infected area, antibodies specific to

the protein are produced by immunologically competent cells and/or

lymphocytes and dispatched to the infected area.

• Lacteals (lymphatics in the villi of the small intestine) serve an

important function in the absorption of fats and other nutrients.

• Plasma filters into the interstitial spaces from blood flowing through

the capillaries.

• Much of this interstitial fluid is absorbed by tissue cells or reabsorbed

by the blood before it flows out of the tissue.

• A small amount of interstitial fluid is left behind.
• If this would continue over even a brief period of time, the increased

interstitial fluid would cause massive oedema.

• This oedema would causes tissue destruction or death.
• This problem is avoided by the presence of lymphatic vessels that act as

‘drains’ to collect the excess fluid and return it to the venous blood

just before it reaches the heart.

STEP 6: Common Disorder of the Lymphatic System (20 minutes)

|Activity: Brainstorming (5 minutes) |

| |

|Ask students to brainstorm on the following question: |

| |

|What are the common disorders of lymphatic system? |

|ALLOW few students to respond |

| |

|WRITE their responses on the flip chart/ board |

| |

|CLARIFY and SUMMARISE by using the content below |

• The most common diseases of the lymphatic system are: enlargement of the

lymph nodes (also known as lymphadenopathy), swelling due to lymph node

blockage (also known as lymphedema) and cancers involving the lymphatic

system,

o The swollen nodes can sometimes be felt in the neck, underarms and

groin.

o Lymphadenopathy is usually caused by infection, inflammation, or

cancer.

o Infections that cause lymphadenopathy include bacterial infections

such as strep throat, locally infected skin wounds, or viral

infections such as mononucleosis or HIV infection.

o Inflammatory or autoimmune conditions occur when a person's immune

system is active, and can result in enlargement of lymph nodes. This

can happen in lupus.

o Lymphoma is cancer of the lymph nodes.

▪ It occurs when lymphocytes grow and multiply uncontrollably.

STEP 7: Key Points (5minutes)

• Lymphatic system is a network of tissue, organs, and vessels that help to

maintain the body’s fluid balance, cleanse the body fluid of foreign

matter and provide immune cells for defence.

• Lymphatic system is composed of lymph, lymphatic plexus, lymphatic

vessels, lymph nodes, lymphocytes and lymphoid tissue.

• The main structures of lymphatic system are tonsils, thymus and spleen
• Functions of the lymphatic system are maintenance of fluid balance in the

internal environment and immunity

• Common disorders of the lymphatic system are: lymphadenopathy, lymphedema

and lymphomas,

STEP 7: Evaluation (5minutes)

• What is lymphatic system?
• What are the components of the lymphatic system?
• What are the functions of lymph system?
• What are the common disorders of the lymphatic system?

Step 8: Assignment (10 minutes)

|Activity: Take Home Assignment (10 minutes) |

| |

|DIVIDE learners in groups or individual. |

| |

|ASK the learners to work on the following assignment |

| |

|Explain structure and functions of lymphatic system |

| |

|ALLOCATE time for learners to do the assignment and submit |

| |

|REFER learners to recommended references |

References

Seeley, R. R., Stephens, T. D., & Tate, P. (2003). Anatomy and Physiology.

New York:

McGraw-Hill.

Shier, A., Butler, J., & Lewis, R. (2004). Hole’s Human Anatomy &

Physiology. New

York: McGraw-Hill.

Thibodeau, G. A., & Patton, K. T. (1999). Anatomy & Physiology. Saint

Louis: Mosby,

Von Hoffman Press, Inc.

Waugh, A., & Grant, A. (2006). Ross and Willson Anatomy and physiology in

Health and

illness. United Kingdom: Churchill Livingstone Elservier.

Scalon, V.C., & Sanders, T. (2007). Essentials of anatomy and physiology

(5th ed.).

Philadelphia, NY: F.A Davis

Tortora, J.G., & Derrickson, B. (2009). Principles of anatomy and

physiology (12th

ed.).Danvers, MA: John Wiley & Sons

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