Introduction to Fixed oils and Fats – PST05210 Basic Pharmacognosy

NTA Level 5 • Semester 2 • PST05210

Introduction to Fixed oils and Fats

Basic Pharmacognosy • Source Session/Topic 34
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 34: Introduction to Fixed oils and Fats

Total Session Time: 120 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• Define fixed oils and fats
• Explain the distribution and occurrence of fixed oils and fats
• List methods for extraction of fixed oils and fats
• Explain the evaluation of fixed oils and fats
• List uses of fixed oils and fats

Resources Needed:

• Flip charts, marker pens, and masking tape
• Black/white board and chalk/whiteboard markers
• LCD Projector and Laptop

SESSION OVERVIEW

|Step |Time |Activity/ |Content |

| | |Method | |

|1 |5 minutes |Presentation |Introduction, Learning Tasks |

|2 |25 minutes |Presentation |Distribution and Characteristics |

| | |Brainstorming |of Fixed Oils and Fats |

|3 |25 minutes |Presentation |Extraction of Fixed Oils and Fats |

|4 |30 minutes |Presentation |Evaluation of Fixed Oils and Fats |

|5 | |Small group |Uses of Fixed Oils and Fats |

| |25 minutes |discussion | |

| | |Presentation | |

|6 |5 minutes |Presentation |Key Points |

|7 |5 minutes |Presentation |Evaluation |

SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning tasks and clarify

ASK students if they have any questions before continuing.

STEP 2: Distribution and Characteristics of Fixed Oils and Fats (25

minutes)

• Occurrence

o Fixed oils and fats are lipids (esters) of long chain fatty acids and

alcohol

o Fixed oils and fats are widely distributed and occur in both vegetative

and reproductive structures

o They are found often in seeds, where they may replace the carbohydrate

as reserve food material

o They are also associated with protein reserves

o As lipids, fats form an essential component of biological membranes

o Fixed oils occur in plant materials as small highly refractive drops

o Oil globules associated with aleurone grains can be well seen in

cotyledons of linseed and colocynth, and in the endosperm of nux vomica

• Physical Characteristics

o Fixed oils and fats are soluble in ether-alcohol, few exceptions such

as castor oil are sparingly soluble in alcohol

o At ordinary temperature fats are semisolid/ solid and fixed oils are

liquid at normal temperature

o Most vegetable oils are liquid at ordinary temperature but animal fats

are solid

o There are exceptions, e.g. coconut oil, in temperate temperature is

solid and tropic temperature it is liquid oil

• Chemical Characteristics

o They are esters of long chain fatty acids and alcohols or closely

related derivatives of alcohols

o The fatty acids forming the oils can be saturated or unsaturated

o Most animal products contain saturated fatty acids while most plant

products contain unsaturated fatty acids

o A special group of unsaturated fatty acids (the ω-3fatty acids) are

vital to human health as they lower cholesterol levels in the body

|Activity: Brainstorming (5 minutes) |

| |

|Ask students to brainstorm on the following question: |

| |

|What are the chemical tests for fixed oils and fats? |

| |

|ALLOW few students to respond? |

| |

|WRITE their responses on the flip chart/ board |

| |

|CLARIFY and SUMMARIZE by using the content below |

• Fixed oils and fats are coloured brown or black with a 1% solution of

Osmic acid

• In dilute tincture of Alkanna, fixed oils and fats slowly turn red
• Saponification reaction
• A cold mixture of equal parts of a saturated solution of potash and

strong solution of ammonia slowly saponifies fixed oils and fats

resulting in observable characteristic soap crystals

STEP 3: Extraction of Fixed Oils and Fats (25 minutes)

• Processes that are employed in the extraction of oil from raw materials

depends on the botanical source of the oil

• Important processes include;

o Decortication –crushing to remove seed coat

o Expression – kernels are placed onto the oil presses and subjected to

pressure with or without application of heat

o Filtration – separates oil from other matters and may be done several

times to attain purity.

o Steaming -at high temperature to inactivate proteins and other

materials e.g. castor oil requires steaming

• Extraction methods used for fixed oils and fats include;

o Expression (cold or hot)

o Solvent extraction

STEP 4: Evaluation of Fixed Oils and Fats (30 minutes)

• Each kind of fixed oil or fat has a specific standard used for evaluation

o Physical standards include;

▪ Specific gravity
▪ Melting point
▪ Refractive index
▪ Optical rotation
▪ Color
▪ Odor
• Chemical standards include;

o Acid Value

o Saponification Value

o Iodine value

o Ester value

STEP 5: Uses of Fixed Oils and Fats (25 minutes)

|Activity: Small Group Discussion (10 minutes) |

| |

|DIVIDE students into small manageable groups |

| |

|ASK students to discuss on the following question |

|What are the uses of fixed oils and fats? |

| |

|ALLOW students to discuss for 10 minutes |

| |

|ALLOW few groups to present and the rest to add points not mentioned|

| |

| |

|CLARIFY and SUMMARIZE by using the contents below |

• They are used in preparation of suppositories
• They are used in tablet coating
• They are employed as emulsifying agents
• They have therapeutic uses e.g. laxatives etc.

STEP 6: Key Points (5 minutes)

• Fixed oils and fats are esters of long chain fatty acids and alcohol
• At ordinary temperature fats are semisolid/ solid and fixed oils are

liquid at normal temperature

• Fixed oils and fats are coloured brown or black with a 1% solution of

Osmic acid

STEP 7: Evaluation (5 minutes)

• What are the physical standards for fixed oils and fats
• What is saponification value?
• What are the uses of fixed oils and fats?

References

Trease, G. E., Evans, W. C., & Evans, D. (2009). Trease and Evans

pharmacognosy. London: Saunders.

Joanne Barnes et al (2002), Herbal medicines 3rd Edition: Pharmaceutical

Press

Wallis, T. E. (2005). Textbook of pharmacognosy. New Delhi: CBS.

Robbers, J. E., Speedie, M. K., Tyler, V. E., & Tyler, V. E. (1996).

Pharmacognosy and pharmacobiotechnology. Baltimore: Williams &

Wilkins.

Heinrich, M., Kinghorn, A. D., Maizels, D., Gibbons, S., & Phillipson, J.

D. (2012). Fundamentals of pharmacognosy and phytotherapy. Edinburgh:

Churchill Livingstone/Elsevier.

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