Adulteration of Medicinal Plants – PST05210 Basic Pharmacognosy

NTA Level 5 • Semester 2 • PST05210

Adulteration of Medicinal Plants

Basic Pharmacognosy • Source Session/Topic 15
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 15: Adulteration of Medicinal Plants

Total Session Time: 60 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• Define adulteration
• List methods of adulteration
• Explain the effects of adulteration

Resources Needed:

• Flip charts, marker pens, and masking tape
• Black/white board and chalk/whiteboard markers
• LCD projector and Laptop

SESSION OVERVIEW

|Step |Time |Activity/ |Content |

| | |Method | |

|1 |05 minutes |Presentation |Introduction, Learning Tasks |

|2 |10 minutes |Presentation |Meaning of Adulteration |

|3 | 25 |Presentation |Methods and Effects of |

| |minutes | |Adulteration |

|4 |05 minutes |Presentation |Key Points |

|5 |05 minutes |Presentation |Evaluation |

|6 | 10minutes |Presentation |Assignment |

SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning objectives and clarify

ASK students if they have any questions before continuing.

STEP 2: Meaning of Adulteration (10 minutes)

• Adulteration is defined as anything causing debasement of a drug
• An adulterant is a medicinal plant which does not conform to official

standards or which does not comply with the requirement of the

pharmacopoeia cheap and easily available in large quantities

o An adulterant must be

• Adulteration or debasement of medicinal plants are of two major types;

o Deliberate adulteration

▪ This is intentional and normally commercial mainly for enhancement

of profits

o Accidental adulteration

• Deliberate adulteration is usually practised when certain medicinal

plants are scarce or expensive

• Adulteration of crude drugs usually involves practices such as

substitution of the original crude drugs partially or fully with other

substances which are either free from or inferior in therapeutic and

chemical properties

• Adulteration can occur through;

o Faulty collection of the drug

o Improper preparation of the drug

o Poor storage condition

o Deliberate practices

• Reasons for adulteration of crude drugs include;

o Scarcity of the drug

o High price of the drug in the market e.g. clove, cardamom

o Contraband drug e.g. opium

STEP 3: Methods and Effects of Adulteration (25 minutes)

• Inferior medicinal plant quality

o Which leads to a sub-standard drug

o This may result from;

▪ Ignorance/carelessness e.g. collection of genuine material

regardless of the time factor –collecting herbs prior/after ideal

time

▪ Collection at incorrect stage of development e.g. coriander – fully

ripe fruits (should be nearly ripe), clove (flowers in bud stage)

▪ Collection of parts which are not medicinally valuable e.g.

Chamomile leaves

▪ Collection of incorrect herb (close resemblance to intended herb)
▪ Imperfect preparation e.g. not removing undesired parts e.g. cork

from ginger rhizome/incorrect drying conditions

▪ Incorrect storage: e.g. volatile oils: cool, dry place in air

tight containers

▪ Inferiority may be avoided by careful selection of the plant

material

• Spoilage of Drug

o When the quality or medicinal value/ usefulness of herb is impaired or

destroyed by bacterial/ fungal action, insects, rodents or other pests

o Normally results from incorrect storage (effects of water/temperature)

o Avoided by careful attention to the drying and storage conditions

• Deterioration

o Occurs when value or quality of the drug has been impaired

• Admixture

o Admixture occurs when another species is added to the medicinally

valuable drug; intentional or accidentally

o This may result from;

▪ Poor collection due to unskilled labour
▪ Presence of plant parts other than those allowed by the

definition

▪ Collection of foreign material (stones, dirt)
• Sophistication with inferior varieties

o This is the deliberate addition of inferior material with the intention

of decreasing medicinal action of the desired drug e.g.

▪ Candle wax coloured yellow and being offered as Beeswax
▪ Addition of flour to powdered ginger with chillies for potency
• Substitution

o Substitution is the addition of an allied drug, or one which is

botanically different e.g. Digitalis thaspi for Digitalis purpurea

• Addition of worthless heavy materials

o Large mass of stomes mixed with liquorice root, pieces of limestone

are added in asafoedita

• Adulteration causes problems in natural drugs

STEP 4: Key Points (5 minutes)

• Adulteration addition of anything into the crude drugs that causes

debasement of that drug

• An adulterant is a medicinal plant which does not conform to official

standards or which does not comply with the requirement of the

pharmacopoeia.

• Deliberate adulteration is usually practiced when the drug in question is

scarce or expensive

STEP 5: Evaluation (5 minutes)

• What is adulteration of crude drugs?
• What is sophistication?
• What are effects of adulteration?

STEP 6: Take Home Assignment (10 minutes)

|Activity: Take Home Assignment (10 minutes) |

| |

|DIVIDE students in groups or individuals |

| |

|ASK the students to work on the following Assignment |

|List monographs of medicinal plants |

|List the effects of adulteration |

|List classes of plants containing toxic substances |

|List toxic substances from plants |

|List common misuses of medicinal plants |

| |

|ALLOCATE time for students to do the assignments and submit |

| |

|REFER students to recommended reference |

References

Trease, G. E., Evans, W. C., & Evans, D. (2009). Trease and Evans

pharmacognosy. London: Saunders.

Joanne Barnes et al (2002), Herbal medicines 3rd Edition: Pharmaceutical

Press

Wallis, T. E. (2005). Textbook of pharmacognosy. New Delhi: CBS.

Robbers, J. E., Speedie, M. K., Tyler, V. E., & Tyler, V. E. (1996).

Pharmacognosy and pharmacobiotechnology. Baltimore: Williams &

Wilkins.

Heinrich, M., Kinghorn, A. D., Maizels, D., Gibbons, S., & Phillipson, J.

D. (2012). Fundamentals of pharmacognosy and phytotherapy. Edinburgh:

Churchill Livingstone/Elsevier.

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