Description of Anti-schistosomals – PST04211 Basic Pharmacology

NTA Level 4 • Semester 2 • PST04211

Description of Anti-schistosomals

Basic Pharmacology • Source Session/Topic 11
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 11: Description of Anti-schistosomals

Total Session Time: 60 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• List indications of anti-schistosomals
• List contraindications of anti-schistosomals
• Describe dose, dosage and course of anti-schistosomals
• List side effects and adverse effects of anti-schistosomals
• Describe interactions and precautions of anti-schistosomals
• Resources Needed:
• Flip charts, marker pens, and masking tape
• Black/white board and chalk/whiteboard markers

SESSION OVERVIEW

Activity/

Step Time Content

Method

1 05 minutes Presentation Introduction, Learning Tasks

Presentation/

2 10 minutes Indications of anti-schistosomals

Buzzing

Presentation/

3 10 minutes Contraindications of anti-schistosomals

Brainstorming

Dose, Dosage and Course of anti-

4 10 minutes Presentation

schistosomals

Presentation/ Side Effects and Adverse Effects of anti-

5 10 minutes

Brainstorming schistosomals

Interactions and Precautions of anti-

6 5minutes Presentation

schistosomals

7 05 minutes Presentation Key Points

8 05 minutes Presentation Evaluation

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SESSION CONTENTS

STEP 1: Presentation of Session Title and Learning tasks (5 minutes)

READ or ASK students to read the learning tasks and clarify

ASK students if they have any questions before continuing.

STEP 2: Indications of Anti-schistosomals (10 minutes)

Activity: Buzzing (5 minutes)

ASK students to pair up and buzz on the following questions for 5 min

What are indications for anti-schistosomals

ALLOW few pairs to respond and let other pairs to add on points not mentioned

WRITE their response on the flip chart/board

CLARIFY and SUMMARIZE by using the content below

• Schistosomiasis is caused by the fluke schistosome
• Praziquantel is the only drug used in treatment of schistosomiasis in Tanzania
• Praziquantel is used in treatment of the common species found in Tanzania which are S.

haematobium and S. mansoni

STEP 3: Contraindications of Anti-schistosomals (10 minutes)

Activity: Brainstorming (5 minutes)

Ask students to brainstorm on the following question:

• What are the contraindications for antischistomiasis drugs?

ALLOW few students to respond

WRITE their responses on the flip chart/ board

CLARIFY and SUMMARISE by using the content below

• Praziquantel is contraindicated in ocular cysticercosis, as parasite destruction in the eye

may cause irreparable damage

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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STEP 4: Dose, Dosage and Course of Antischistosomiasis Drugs

(10 minutes)

• Praziquantel
o 40mg – 60mg/kg body weight as a single dose

Or

o Three doses of 20mg/kg body weight at an interval of 4 to 6 hours for one day

STEP 5: Side Effects and Adverse Effects of Antischistosomiasis Drugs

(10 minutes)

Activity: Brainstorming (5 minutes)

Ask students to brainstorm on the following question:

• What are side effects and adverse effects of anti-schistosomals?

ALLOW few students to respond

WRITE their responses on the flip chart/ board

CLARIFY and SUMMARISE by using the content below

Mild and transient adverse effects are common; they begin within several hours after

ingestion and may persist for hours to one day

• Most frequent are headache, dizziness, drowsiness, and lassitude; others include nausea,

vomiting, abdominal pain, loose stools, pruritus, urticaria, arthralgia, myalgia, and low-

grade fever

• Mild and transient elevations of liver enzymes have been reported
• Several days after starting Praziquantel, low-grade fever, pruritus and skin rashes

(macular and urticarial)

STEP 6: Interactions and Precautions of Antischistosomals (5 minutes)

• Because the drug induces dizziness and drowsiness, patients should not drive during

therapy and should be warned regarding activities requiring particular physical

coordination or alertness

• Some workers also caution against use of the drug in spinal neurocysticercosis

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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Step 7: Key Points (5minutes)

• Schistosomiasis is caused by the fluke schistosome
• Drug of choice is called Praziquantel
• Praziquantel is contraindicated in ocular cysticercosis

STEP 8: Evaluation (5minutes)

• What are the indications of anti-schistosomals?
• What are the contraindications of anti-schistosomals?
• What are the dose, dosage and course of anti-schistosomals?
• What are side effects and adverse effects of anti-schistosomals?

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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References

Robert, L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael.

2014. Pharmacotherapy: a pathophysiologic approach (9th ed.). New York,

McGraw-Hill Education.

Ministry Of Health and Social Welfare. 2013. Standard Treatment Guidelines &

National Essential Medicines List Tanzania Mainland (4th ed.). Dar es

salaam, Tanzania government printers.

Sally, S.R, Jeanne C.S. 2000. Introductory Clinical Pharmacology (6th ed) New York,

Lippincott Williams and Wilkins

School of Pharmaceutical sciences. 2011. Tanzania Pharmaceutical Handbook

(2nd ed.). Dar es Salaam, ARDHI University press.

The Royal Pharmaceutical Society of Great Britain. 2007. Martindale, the Extra

Pharmacopoeia (5TH ed). London, pharmaceutical press.

The Royal Pharmaceutical Society of Great Britain. 2009. British National Formulary

(59th ed). London, BMJ Group and RPS Publishing.

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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