Description of Hormonal Contraceptives – PST04211 Basic Pharmacology

NTA Level 4 • Semester 2 • PST04211

Description of Hormonal Contraceptives

Basic Pharmacology • Source Session/Topic 35
Full source-text version: all educational wording from the extracted learning source is retained; only presenter/tutor metadata and web-layout noise are removed, while formatting is improved for readability.

Session 35: Description of Hormonal Contraceptives

Methods

Total Session Time: 60 minutes

Prerequisites

• None

Learning Tasks

By the end of this session students are expected to be able to:

• List indications of hormonal contraceptives
• List contraindication of hormonal contraceptives
• Describe dose, dosage and course of hormonal contraceptives
• List side effects and adverse effects of hormonal contraceptives
• Describe interaction and precaution of hormonal contraceptives

Resources Needed:

• Flip charts, marker pens, and masking tape
• Black/white board and chalk/whiteboard markers
• Overhead projector and computer

SESSION OVERVIEW

Activity/

Step Time Content

Method

1 05 minutes Presentation Introduction, Learning Tasks

Presentation/

2 05 minutes Indications of Hormonal Contraceptives

Buzzing

Presentation/ Contraindications of Hormonal

3 10 minutes

Brainstorming Contraceptives

Dose, Dosage and Course of Hormonal

4 20 minutes Presentation

Contraceptives

Presentation/ Side Effects and Adverse Effects of Hormonal

5 05 minutes

Brainstorming Contraceptives

Interactions and Precaution of Hormonal

6 05minutes Presentation

Contraceptives

7 05 minutes Presentation Key Points

8 05 minutes Presentation Evaluation

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STEP 1: Presentation of Session Title and Learning Tasks (5 minutes)

READ or ASK students to read the learning tasks and clarify

ASK students if they have any questions before continuing.

STEP 2: Indications of Hormonal Contraceptives (5 minutes)

Activity: Buzzing (5 minutes)

ASK students to pair up and buzz on the following question for 2 minutes

• What hormonal contraceptives are used in clinical practice?
• What are indications for hormonal contraceptives?
• ALLOW few pairs to respond and let other pairs to add on points not mentioned

WRITE their response on the flip chart/board

CLARIFY and SUMMARIZE by using the content below

• Hormonal contraceptives are either given orally or by injection
• Oral contraceptive fall into two major categories:

o Combined oral contraceptives) COCs)

o Progestogen Only Pills (POPs)

• Hormonal contraceptives are indicated in:

o Alleviating menopausal symptoms

o In women with early natural or surgical menopause

o Primarily for prevention of conception

o Treatment of dysfunctional uterine bleeding,

o Treatment of dysmenorrheal

o Treatment of endometriosis.

o In management of Menorrhagia

o Treatment of premenstrual symptoms

o Post Coital Contraception (―morning-after pill‖)

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STEP 3: Contraindications of Hormonal Contraceptives (10 minutes)

Activity: Brainstorming (5 minutes)

Ask students to brainstorm on the following question:

• What are contraindications of hormonal contraceptives?

ALLOW few students to respond

WRITE their responses on the flip chart/ board

CLARIFY and SUMMARISE by using the content below

• Hormonal contraceptives are contraindicated in patients with:

o Thrombophlebitis

o Thromboembolic phenomena

o Cardiovascular and

o Cerebrovascular disorders or a past history of these conditions

o Treat vaginal bleeding when the cause is unknown

• They should be avoided in patients with known or suspected tumors of the breast or

estrogen-dependent neoplasm

• They are contraindicated in patient with the following conditions:

o Liver disease

o Pregnancy

o Severe headaches especially associated with visual disturbances

o Numbness or paresis of extremities

o Unexplained chest pain or shortness of breath

o Severe leg pains

STEP 4: Dose, Dosage and Course of Hormonal Contraceptives

(30 minutes)

• Hormonal contraceptives can be administered orally, intramuscular or through

intradermal

o Combined Oral Contraceptive (COP)

 The use of COP in contraception

 In pack of 28 pills, first 21 have hormone and the last 7 have no hormone

 Take one pill each day until the pack is empty

o Menopausal symptoms with uterus

 Give one tablet of combined oral contraceptive daily

o Menopausal symptom and osteoporosis prophylaxis (with progesterone for 12-14

days per cycle in women with intact uterus)

 10-50 micrograms daily for 21 days repeated after 7 days tablet free period.

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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o Female hypogonadism

 10-50micrograms daily

o Post Coital Contraception (―morning-after pill‖)

 The method is applicable mostly after rape and unprotected sexual intercourse

where pregnancy is not desired

 Within 3 days (72 hours) of unprotected sexual intercourse, give

 Combined oral Contraceptive 100 microgram ethinylestradiol and 500

micrograms levonorgestrel (2 high dose COC tablets)

Or

 When this preparation is not available, use 3 tablets each containing 30-35

micrograms ethinyloetradiol and 150-250 microgram levonorgestrel (3 low dose

COC tablets)

• Management of the dysfunctional uterine bleeding

o Norethisterone (Primolut N) 5mg 12hourly for 10 -14 days

COC (E+P) Combined oral contraception 2-3 cycles

• Progesterone only pills (POP)

o This type is suitable for lactating mothers or women with mild or moderate

hypertension. Start 6 week after birth

o Use of POP in contraception

o Take one tablet every daily at the same time

o Use of POP in management of dysmenorrhea. Give POP 5mg three times daily by

mouth from day 5 to 24 for 3-4 cycles

o Use of POP in management premenstrual syndrome. Give POP 5mg 2-3 times

• Progesterone injection

o This type is suitable for lactating mothers or women with mild or moderate

hypertension

• Use of progesterone in contraception

o Depo Provera 150m intramuscular after every three month

• Use of progesterone injection in management of dysfunctional uterine bleeding

o Deep intramuscular into buttock of 5-10mg daily for 5-10 days until 2days before

onset of menstruation

• Injectable Contraceptive:
o Medroxy progesterone acetate IM 150 mg every three months
• Implant Contraceptive:

o Levonorgestrel in six plastic capsules is implanted in the left upper arm made under

local anesthesia

o Levonorgestrel is effective for five years and is recommended for women who have

completed their family or not ready for sterilization or those not able to take estrogen

containing contraceptives

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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STEP 5: Side Effects and Adverse Effects of Hormonal Contraceptives

(20 Minutes)

Activity: Brainstorming (5 minutes)

Ask students to brainstorm on the following question:

• What are side effects and adverse effects of hormonal contraceptives?

ALLOW few students to respond

WRITE their responses on the flip chart/ board

CLARIFY and SUMMARISE by using the content below

• Side effects of estrogen hormone

o Nausea and vomiting, abdominal cramps and bloating, weight changes

o Breast enlargement and tenderness

o Premenstrual-like syndrome

o Changes in libido, depression, mood changes, headache, migraine, dizziness,

o Leg cramps (rule out venous thrombosis)

o Headache has been reported

• Side effects and adverse effects of progestogen

o Premenstrual like syndrome which includes; bloating, fluid retention, breast

tenderness

o Weight change, nausea, headache, dizziness, insomnia

o Drowsiness, depression, change in libido

o Skin reactions including urticaria, pruritus, rash, and acne)

o Hirsutism and alopecia

o Jaundice and anaphylactic reactions

o Menstrual disturbances

STEP 6: Interactions and Precautions of Hormonal Contraceptives

(5 minutes)

• The following drugs reduces the effects of the oral contraceptive so advise to use other

contraceptive methods:

o Hypnotic/sedatives anti-migraine medication, barbiturates, chloral hydrate, diazepam

o Antacid: Aluminium hydroxide, magnesium hydroxide, magnesium trisilicate

o Anti TB as rifampicin

o Antiretroviral as Nevirapine and Ritonavir

o Certain antibiotics as Ampicillin and other Penicillins and Tetracyclines

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• The following groups of drugs are made less by oral contraceptives; prescribers might

consider increasing the doses of the following drugs, known with careful monitoring:

o Anticonvulsant

o Ant diabetic agents

o Anticoagulants

o Antihypertensive agents (methyldopa)

o Corticosteroid

o Hypnotics, sedatives or other CNS depressants

Step 7: Key Points (5minutes)

• Hormonal contraception are primarily indicated for contraception
• Hormonal contraception are contraindicated in pregnancy, thromboembolism and in liver

problems

• Hormonal contraception are administered orally, parenteral or through intradermal

implants

• Common side effects of hormonal contraceptives are nausea and vomiting, abdominal

cramps and bloating, weight changes

• Hormonal contraception effects are reduced by hypnotic, antacids, antiTB and

antiretroviral

• Hormonal contraceptive reduces the effects of other drugs like antidiabetics,

corticosteroids, anticonvulsants and anticoagulants

STEP 8: Evaluation (5minutes)

• Mention indications of hormonal contraceptives?
• Mention the Contraindication of hormonal contraceptives?
• What are the dose, dosage and course of hormonal contraceptives?
• What are side effects and adverse effects of hormonal contraceptives??
• Describe interaction and precaution of hormonal contraceptives?

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References

Robert L. T., Gary C. Y., Gary R. M., Barbara G. W., & Michael, L.. (2014).

Pharmacotherapy: A Pathophysiologic Approach (9th ed.). New York, McGraw-Hill

Education.

Ministry of Health and Social Welfare. ( 2013). Standard Treatment Guidelines & National

Essential Medicines List Tanzania Mainland (4th ed.). Dar es salaam, Tanzania

government printers.

Sally S.R., Jeanne C.S. (2000). Introductory Clinical Pharmacology (6th ed) New York,

Lippincott Williams and Wilkins.

School of Pharmaceutical sciences. (2011). Tanzania Pharmaceutical Handbook (2nd ed.).

Dar es Salaam, ARDHI University press.

The Royal Pharmaceutical Society of Great Britain. (2007). Martindale: The Extra

Pharmacopoeia (5TH ed). London, pharmaceutical press.

The Royal Pharmaceutical Society of Great Britain. (2009). British National Formulary

(59th ed). London, BMJ Group and RPS Publishing.

PST 04211 Basic Pharmacology NTA Level 4 Semester 2 Facilitator Guide

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